门冬胰岛素联合不同剂量维生素D治疗肥胖孕妇妊娠期糖尿病的效果研究  

Effect of Insulin Aspart Combined with Different Doses of Vitamin D on Obese Pregnant Women with Gestational Diabetes

作　　者：张琬 ZHANG Wan(Obstetrics and Gynecology Department of Shangqiu Central Hospital,Shangqiu 476000,Henan Province,China)

机构地区：[1]商丘市中心医院妇产科,河南商丘476000

出　　处：《罕少疾病杂志》2025年第4期155-157,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的对肥胖孕妇妊娠期糖尿病患者,采取门冬胰岛素联合不同剂量维生素D进行治疗,评估治疗效果。方法于2022年1月至2024年1月期间,选取我院收治的83例肥胖妊娠期糖尿病孕妇随机分为2组(分组方法为数字表法),A组42例和B组41例,分别予以门冬胰岛素+高剂量维生素D(30U/次)和门冬胰岛素+低剂量维生素D(10U/次)治疗,对比分析两组治疗情况。结果相较于B组,A组治疗后的血糖水平、胰岛素抵抗、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、脂肪素(Visfatin)、瘦素(Leptin)更低,胰岛素β细胞功能指数(HOMA-β)更高,不良妊娠事件更少(P<0.05)。结论在治疗肥胖孕妇妊娠期糖尿病时,相较于门冬胰岛素联合低剂量维生素D,应用门冬胰岛素联合高剂量维生素D可提高血糖控制效果,促进患者胰岛素抵抗减轻和胰岛功能改善,也能进一步调节炎症因子及脂质代谢,改善妊娠结局。Objective To evaluate the therapeutic effect of insulin aspart combined with different doses of vitamin D on obese pregnant women with gestational diabetes.Methods uring the period from January 2022 to January 2024,83 obese pregnant women with diabetes in pregnancy treated in our hospital were randomly divided into two groups(grouping method:numerical table method),42 cases in Group A and 41 cases in Group B,who were treated with asparagus insulin+high-dose vitamin D(30U/time)and asparagus insulin+low-dose vitamin D(10U/time),Compare and analyze the treatment outcomes of two groups.Results Compared with group B,group A had lower blood glucose levels,insulin resistance,interleukin-2(IL-2),interleukin-6(IL-6),visfatin,and leptin levels,higher HOMA-βcell function index,and fewer adverse pregnancy events after treatment(P<0.05).Conclusion When treating obese pregnant women with gestational diabetes,compared with insulin aspart combined with low-dose vitamin D,the application of insulin aspart combined with high-dose vitamin D can improve the effect of blood glucose control,promote the reduction of insulin resistance and the improvement of pancreatic islet function,further regulate inflammatory factors and lipid metabolism,and improve pregnancy outcomes.

关 键 词：门冬胰岛素 维生素D 肥胖孕妇 妊娠期糖尿病 炎症反应 脂质代谢 妊娠结局 

分 类 号：R587.1[医药卫生—内分泌]