SAA/CRP、PCT、NLR联合检测在小儿感染性腹泻鉴别诊断中的应用价值  

Application value of combined detection of SAA/CRP,PCT and NLR in the differential diagnosis of infectious diarrhea in children

作　　者：尹欢 刘舒南 YIN Huan;LIU Shunan(No.1 Ward of Pediatrics Department,the People's Hospital of Daye City,Daye 435100,China)

机构地区：[1]大冶市人民医院儿科一病区,湖北大冶435100

出　　处：《临床医学研究与实践》2025年第11期98-101,共4页Clinical Research and Practice

摘　　要：目的探讨血清淀粉样蛋白(SAA)/C反应蛋白(CRP)、降钙素原(PCT)、中性粒细胞/淋巴细胞比值(NLR)联合检测在小儿感染性腹泻鉴别诊断中的应用价值。方法调取大冶市人民医院电子病历系统中2020年6月至2023年12月在儿科住院的127例感染性腹泻患儿的病历资料,根据不同致病微生物将其分为细菌组(n=72)和病毒组(n=55)。比较两组的一般资料、临床症状、SAA/CRP、PCT水平、NLR;绘制受试者工作特征(ROC)曲线分析SAA/CRP、PCT、NLR联合检测的应用价值。结果两组的年龄、性别、病程、体温及呕吐、腹痛、脱水占比比较,差异无统计学意义(P>0.05)。细菌组的SAA/CRP、PCT水平及NLR高于病毒组(P<0.05)。SAA/CRP、PCT、NLR鉴别诊断小儿细菌性腹泻和病毒性腹泻的曲线下面积(AUC)分别为0.695、0.756、0.651,三者联合检测的AUC为0.897;SAA/CRP、PCT、NLR联合检测的AUC高于单独检测(P<0.05)。结论SAA/CRP、PCT、NLR联合检测可有效鉴别诊断小儿感染性腹泻类型,具有较好的临床应用价值。Objective To investigate the application value of combined detection of serum amyloid A(SAA)/C-reactive protein(CRP),procalcitonin(PCT)and neutrophil to lymphocyte ratio(NLR)in the differential diagnosis of infectious diarrhea in children.Methods The medical records of 127 children with infectious diarrhea who were hospitalized in pediatrics department from June 2020 to December 2023 in the electronic medical record system of the People's Hospital of Daye City were collected and divided into bacterial group(n=72)and virus group(n=55)according to different pathogenic microorganisms.The general data,clinical symptoms,SAA/CRP,PCT level and NLR were compared between the two groups;the receiver operating characteristic(ROC)curve was drawn to analyze the application value of SAA/CRP,PCT and NLR combined detection.Results There were no significant differences in age,gender,course of disease,body temperature,vomiting,abdominal pain and dehydration between the two groups(P>0.05).The SAA/CRP,PCT level and NLR in the bacterial group were higher than those in the virus group(P<0.05).The areas under curve(AUC)of SAA/CRP,PCT and NLR in differential diagnosis of bacterial diarrhea and viral diarrhea in children was 0.695,0.756 and 0.651,respectively,the AUC of combined detection of SAA/CRP,PCT and NLR was 0.897;the AUC of combined detection of SAA/CRP,PCT and NLR was higher than that of single detection(P<0.05).Conclusion The combined detection of SAA/CRP,PCT and NLR can effectively identify and diagnose the types of infectious diarrhea in children,and has good clinical application value.

关 键 词：血清淀粉样蛋白 C反应蛋白 降钙素原 中性粒细胞/淋巴细胞比值 小儿 感染性腹泻 

分 类 号：R446.11[医药卫生—诊断学]