NT-proBNP、FIB、NLR在慢性心力衰竭患者中的诊断价值  

Diagnostic value of NT-proBNP,FIB and NLR in patients with chronic heart failure

作　　者：吴芬 张丽芬 郭振伟 程广杰 胡慧营 冯宁 赵顺锋 WU Fen;ZHANG Lifen;GUO Zhenwei;CHENG Guangjie;HU Huiying;FENG Ning;ZHAO Shunfeng(Laboratory Department,the Third People's Hospital of Liaocheng,Liaocheng 252000,China)

机构地区：[1]聊城市第三人民医院检验科,山东聊城252000

出　　处：《临床医学研究与实践》2025年第11期102-105,共4页Clinical Research and Practice

摘　　要：目的探讨N-末端B型脑钠肽前体(NT-proBNP)、纤维蛋白原(FIB)、中性粒细胞与淋巴细胞比值(NLR)在慢性心力衰竭(CHF)患者中的诊断价值。方法选取聊城市第三人民医院接收的101例CHF患者为观察组,参照心功能分级将其分为Ⅰ~Ⅱ级组(33例)、Ⅲ级组(25例)、Ⅳ级组(43例),另选取同期96名健康体检者为对照组。比较两组的NT-proBNP、FIB、全身免疫炎症指数(SII)、NLR、单核细胞与淋巴细胞比值(MLR)、血小板与淋巴细胞比值(PLR)以及全身炎症反应指数(SIRI);比较不同心功能分级CHF患者的NT-proBNP、FIB、SII、NLR、MLR、PLR及SIRI;采用多因素Logistic回归分析探讨影响CHF发生的因素;采用受试者工作特征(ROC)曲线分析指标单独及联合检测诊断CHF的效能。结果观察组的NT-proBNP、FIB、SII、NLR、MLR、PLR及SIRI均显著高于对照组,差异具有统计学意义(P<0.05)。Ⅲ级组、Ⅳ级组的NT-proBNP、FIB、SII、NLR、MLR、PLR及SIRI均显著高于Ⅰ~Ⅱ级组,Ⅳ级组的NT-proBNP、FIB、SII、NLR、MLR、PLR及SIRI均显著高于Ⅲ级组,差异具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,NT-proBNP、FIB、NLR是CHF发生的影响因素。ROC曲线分析显示,NT-proBNP、FIB、NLR联合检测诊断CHF的曲线下面积(AUC)为0.970。结论NT-proBNP、FIB、NLR是CHF发生的影响因素,三者联合检测有助于提高CHF的诊断效能。Objective To investigate the diagnostic value of N-terminal pro-B-type natriuretic peptide(NT-proBNP),fibrinogen(FIB)and neutrophil to lymphocyte ratio(NLR)in patients with chronic heart failure(CHF).Methods A total of 101 patients with CHF admitted in the Third People's Hospital of Liaocheng were selected as observation group.According to the cardiac function classification,the patients were divided into gradeⅠ-Ⅱgroup(33 cases),gradeⅢgroup(25 cases)and gradeⅣgroup(43 cases).In addition,96 healthy physical examination subjects were selected as control group.The NT-proBNP,FIB,systemic immune-inflammation index(SII),NLR,monocyte to lymphocyte ratio(MLR),platelet to lymphocyte ratio(PLR)and systemic inflarnmation response index(SIRI)were compared between the two groups;NT-proBNP,FIB,SII,NLR,MLR,PLR and SIRI in CHF patients with different cardiac function grades were compared;multivariate Logistic regression analysis was used to explore the factors affecting the occurrence of CHF;receiver operating characteristic(ROC)curve was used to analyze the efficacy of single and combined detection of indicators in the diagnosis of CHF.Results The NT-proBNP,FIB,SII,NLR,MLR,PLR and SIRI in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The NT-proBNP,FIB,SII,NLR,MLR,PLR and SIRI in the gradeⅢgroup and the gradeⅣgroup were significantly higher than those in the gradeⅠ-Ⅱgroup;NT-proBNP,FIB,SII,NLR,MLR,PLR and SIRI in the gradeⅣgroup were significantly higher than those in the gradeⅢgroup,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis results showed that NT-proBNP,FIB and NLR were the risk factors for CHF.ROC curve analysis showed that the area under the curve(AUC)of combined detection of NT-proBNP,FIB and NLR in the diagnosis of CHF was 0.970.Conclusion NT-proBNP,FIB and NLR are influencing factors for CHF,and the combined detection of the three is helpful to improve t

关 键 词：慢性心力衰竭 N-末端B型脑钠肽前体 纤维蛋白原 中性粒细胞与淋巴细胞比值 

分 类 号：R541.61[医药卫生—心血管疾病]