流感病毒与腺病毒所致肺炎患儿嗜酸性粒细胞、C反应蛋白、降钙素原水平差异分析  

Analysis of Differences in Eosinophils,C-Reactive Protein,and Procalcitonin Levels in Children with Pneumonia Caused by Influenza Virus and Adenovirus

作　　者：李晓娟[1] LI Xiaojuan(Department of Pediatrics,The People‘s Hospital of Anyang,Anyang Henan 455000,China)

机构地区：[1]安阳市人民医院儿科,河南安阳455000

出　　处：《临床研究》2025年第4期20-24,共5页Clinical Research

摘　　要：目的研究流感病毒与腺病毒所致肺炎患儿嗜酸性粒细胞、C反应蛋白、降钙素原水平差异。方法选取2022年6月至2024年6月在安阳市人民医院接受治疗的80例由病毒感染引起的肺炎患儿的临床资料进行回顾性分析。根据患儿感染病毒类型的不同进行分组,流感病毒感染所致肺炎的患儿为对照组(40例),而腺病毒感染所致肺炎的患儿为观察组(40例)。对两组患儿的常见临床症状及体征进行比对,同时对两组患儿的血液实验室指标进行对比分析,分析影响患儿出现腺病毒感染所致肺炎的影响因素,并评估不同指标预测腺病毒感染所致肺炎的价值。结果观察组患儿的体温低于对照组患儿,差异有统计学意义(P<0.05),观察组患儿的白细胞计数、红细胞计数、C反应蛋白明显高于对照组患儿,差异有统计学意义(P<0.05)。Logistic回归分析结果显示,患儿体温较低、白细胞计数升高、红细胞计数升高、C反应蛋白升高是患儿发生腺病毒感染所致肺炎的影响因素(P<0.05)。利用多因素分析的结果构建列线图预测模型,而后使用患儿的体温、白细胞计数、红细胞计数、C反应蛋白、列线图模型对患儿发生腺病毒感染所致肺炎的情况进行ROC曲线的预测,ROC曲线下面积分别为0.832、0.783、0.813、0.818、0.963。结论腺病毒感染与流感病毒引起肺炎患儿的体温、白细胞计数、红细胞计数以及C反应蛋白水平存在差异,在临床诊断过程中,上述指标可以辅助临床进行鉴别诊断,且建立的列线图模型对患儿发生腺病毒感染所致肺炎具有较好的预测价值。Objective To study the differences in eosinophils,C-reactive protein,and procalcitonin levels in children with pneumonia caused by influenza virus versus adenovirus.Methods A retrospective analysis was conducted on the clinical data of 80 children with pneumonia caused by viral infections who were treated at The People‘s Hospital of Anyang from June 2022 to June 2024.According to the type of virus infection,the children were divided into two groups:the control group consisted of 40 children with pneumonia caused by influenza virus,while the observation group included 40 children with pneumonia caused by adenovirus.Common clinical symptoms and signs in both groups were compared,and laboratory blood indicators were analyzed to identify the factors affecting pneumonia caused by adenovirus infection and to assess the predictive value of different indicators for pneumonia caused by adenovirus.Results The body temperature of children in the observation group was lower than that of the control group,with a statistically significant difference(P<0.05).The white blood cell count,red blood cell count,and C-reactive protein levels in the observation group were significantly higher than those in the control group,showing statistical significance(P<0.05).Logistic regression analysis indicated that lower body temperature,elevated white blood cell count,elevated red blood cell count,and elevated C-reactive protein levels were factors influencing the occurrence of pneumonia due to adenovirus infection in children(P<0.05).A nomogram prediction model was constructed based on the results of multivariate analysis,and ROC curve analysis was used to predict the occurrence of pneumonia due to adenovirus infection using the children’s body temperature,white blood cell count,red blood cell count,C-reactive protein levels,and the nomogram model.The areas under the ROC curves were 0.832,0.783,0.813,0.818,and 0.963,respectively.Conclusion There are differences in body temperature,white blood cell count,red blood cell count,and C-reactiv

关 键 词：流感病毒 腺病毒 肺炎 降钙素原 白细胞计数 

分 类 号：R511.7[医药卫生—内科学]