清热化湿健脾汤联合奥美拉唑碳酸氢钠干混悬剂治疗胃溃疡的内镜下溃疡愈合率观察  

Observation of Endoscopic Ulcer Healing Rate in Gastric Ulcer Patients Treated with Qingre Huashi Jianpi Decoction Combined with Omeprazole and Sodium Bicarbonate Dry Suspension

作　　者：马海丽 吉春阳 MA Haili;JI Chunyang(Gastroenterology Room,The First People's Hospital of Zhumadian,Zhumadian Henan 463000,China;Department of Gastroenterology,Zhumadian Central Hospital,Zhumadian Henan 463000,China)

机构地区：[1]驻马店市第一人民医院胃肠镜室,河南驻马店463000 [2]驻马店市中心医院消化内科,河南驻马店463000

出　　处：《临床研究》2025年第4期116-119,共4页Clinical Research

摘　　要：目的探究清热化湿健脾汤联合奥美拉唑碳酸氢钠干混悬剂治疗胃溃疡的愈合率情况。方法选取2020年4月至2023年4月于驻马店市第一人民医院收治的110例胃溃疡患者,随机分为观察组(n=55)和对照组(n=55)。对照组给予奥美拉唑碳酸氢钠干混悬剂治疗,观察组在对照组基础上给予清热化湿健脾汤联合治疗。比较两组患者临床疗效、主症改善程度、溃疡愈合质量、不良反应及复发情况。结果观察组治疗有效率(96.36%)高于对照组(83.64%),差异有统计学意义(P<0.05);两组治疗后各项症状积分均较治疗前降低,且观察组低于对照组,差异均有统计学意义(P<0.05);观察组治疗后再生黏膜成熟度Sc期(83.64%)高于对照组(41.82%),差异有统计学意义(P<0.05);两组治疗后黏蛋白5AC(MUC5AC)信使核糖核酸(mRNA)表达均较治疗前升高,且观察组高于对照组,差异均有统计学意义(P<0.05);两组治疗后内皮素A受体(ETAR)mRNA表达均较治疗前降低,且观察组更低,差异均有统计学意义(P<0.05);两组患者在治疗中均未出现明显不良反应。结论清热化湿健脾汤联合奥美拉唑碳酸氢钠干混悬剂治疗胃溃疡疗效明显,可提高溃疡愈合质量,且安全可靠。Objective To investigate the healing rate of gastric ulcers treated with Qingre Huashi Jianpi Decoction combined with Omeprazole and Sodium Bicarbonate Dry Suspension.Methods A total of 110 gastric ulcer patients admitted to The First People's Hospital of Zhumadian from April 2020 to April 2023 were selected and randomly divided into an observation group(n=55)and a control group(n=55).The control group received treatment with Omeprazole and Sodium Bicarbonate Dry Suspension,while the observation group received additional treatment with Qingre Huashi Jianpi Decoction.The clinical efficacy,improvement of main symptoms,quality of ulcer healing,adverse reactions,and recurrence rates were compared between the two groups.Results The effective treatment rate in the observation group(96.36%)was higher than that in the control group(83.64%),with statistically significant differences(P<0.05).After treatment,the symptom scores in both groups decreased compared to before treatment,with the observation group having lower scores than the control group,and all differences were statistically significant(P<0.05).The maturity rate of regenerated mucosa stage Sc in the observation group(83.64%)was significantly higher than that in the control group(41.82%),with statistical significance(P<0.05).The mRNA expression of mucin 5AC(MUC5AC)increased post-treatment in both groups compared to pre-treatment,with the observation group showing higher levels than the control group,yielding statistically significant differences(P<0.05).The mRNA expression of endothelin A receptor(ETAR)decreased in both groups after treatment,with the observation group showing a lower level,and the differences were statistically significant(P<0.05).No significant adverse reactions were observed in either group during the treatment.Conclusion The combination of Qingre Huashi Jianpi Decoction with Omeprazole and Sodium Bicarbonate Dry Suspension demonstrates significant efficacy in treating gastric ulcers,improving ulcer healing quality,and is safe and reliable.

关 键 词：清热化湿健脾汤 奥美拉唑碳酸氢钠干混悬剂 胃溃疡 溃疡愈合率 

分 类 号：R656.62[医药卫生—外科学]