新型贝美前列素眼溶液抑菌剂浓度及抑菌效力研究  

Study on the bacteriostatic concentration and antibacterial efficacy of a new bimatoprost ophthalmic solution

作　　者：孙蓉 李玉柱 刘璐 SUN Rong;LI Yuzhu;LIU Lu(Shanghai Likory Biological Engineering Co.,Ltd.,Shanghai 201707,China)

机构地区：[1]上海利康瑞生物工程有限公司,上海201707

出　　处：《上海医药》2025年第3期78-80,84,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:研究与分析新型贝美前列素眼溶液不同抑菌剂添加量的抑菌效力。方法:在其他成分处方量一致的情况下,设计抑菌剂苯扎氯铵高、中、低3个浓度,按照中国药典2020年版开展抑菌效力研究。结果:低浓度满足B标准,中浓度和高浓度满足A标准。结论:在该新型贝美前列素眼溶液处方条件下,不同浓度苯扎氯铵满足不同抑菌效力要求,这可为该产品的处方提供参考。Objective:To study and analyze the antibacterial efficacy of different concentrations of bacteriostatic agent in a new bimatoprost ophthalmic solution.Methods:With other formulation components held constant,three concentrations(high,medium,and low)of benzalkonium chloride,a bacteriostatic agent,were tested for their antimicrobial activity according to the guidelines outlined in the 2020 edition of the Chinese Pharmacopoeia.Results:The low concentration of benzalkonium chloride met the B standard for microbiocidal efficacy,while the medium and high concentrations achieved the A standard as per the specified criteria.Conclusion:Under the formulation conditions of the bimatoprost ophthalmic solution,varying different concentrations of benzalkonium chloride satisfy different antimicrobial activity requirements.These findings provide valuable references for the development and optimization of this pharmaceutical product.

关 键 词：贝美前列素 眼溶液 抑菌效力 

分 类 号：R944.9[医药卫生—药剂学] R988.1[医药卫生—药学]