非奈利酮片致贫血1例分析  

One Case of Anemia Caused by Finerenone Tablets

作　　者：刘辰霈 杜雨芃 林燕[1,2] LIU Chenpei;DU Yupeng;LIN Yan(Department of Nephrology,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300382,China;Department of Nephrology,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300382,China;Graduate School,Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津中医药大学第一附属医院肾病科,天津300382 [2]国家中医针灸临床医学研究中心肾病科,天津300382 [3]天津医科大学研究生院,天津300070

出　　处：《中国药物警戒》2025年第3期334-336,共3页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金资助项目(81373609);国家中医药管理局曹式丽全国名老中医药专家传承工作室建设项目(国中医药人教函〔2012〕149号);国家中医药管理局第四批全国中医临床优秀人才研修项目(国中医药人教发〔2017〕124号);天津市名中医林燕传承工作室建设项目(tjmzy2404)。

摘　　要：目的分析非奈利酮片致贫血的不良反应,为临床医师合理应用非奈利酮提供参考。方法结合现有研究,对1例疑似由非奈利酮片导致血红蛋白(HGB)下降的糖尿病肾病(DKD)患者诊治经过、危险因素、可能机制及防治策略进行分析总结。结果1例DKD患者服用非奈利酮片4个月后出现HGB下降,药物剂量增加后HGB进一步降低,经关联性评价,推测患者贫血可能由非奈利酮片所致,患者停药后HGB逐步回升。结论临床应加强非奈利酮片致贫血不良反应的重视,做到尽早识别并及时干预,防止严重不良反应的发生。Objective To analyze anemia caused by finerenone based on a case report in order to provide a reference for rational use of finerenone.Methods The treatment process,risk factors,possible mechanism and treatment regimens related to a diabetic kidney disease(DKD)patient with hemoglobin decline that was believed to have been caused by finerenone were analyzed based on research currently available.Results A DKD patient experienced hemoglobin decline after taking finerenone for four months.With an increase in drug dosage,the patient’s hemoglobin continued to decrease.With a Naranjo’s score of 8,the patient’s anemia was considered to have been caused by finerenone.After the patient discontinued the drug,hemoglobin gradually recovered during follow-up.Conclusion Clinicians should be alert to finerenone-induced anemia.Early identification and immediate interventions are crucial to preventing serious adverse drug reactions.

关 键 词：非奈利酮 糖尿病肾病 血红蛋白 贫血 药品不良反应 

分 类 号：R977[医药卫生—药品] R994.11[医药卫生—药学]