碘佛醇注射液致急性肝损伤1例分析  

One Case of Acute Hepatic Injury Caused by Ioversol Injection

作　　者：于莉[1] 谭喜莹[1] YU Li;TAN Xiying(Department of Pharmacy,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing Jiangsu 210029,China)

机构地区：[1]江苏省中医院药学部,江苏南京210029

出　　处：《中国药物警戒》2025年第3期343-345,共3页Chinese Journal of Pharmacovigilance

基　　金：江苏省药学会恒瑞医院药学基金科研项目(H202021);江苏省药品不良反应监测省级哨点项目;南京药学会药物临床综合评价科研项目(2023ZP09)。

摘　　要：目的探讨碘佛醇注射液引起急性肝损伤的发生特点,为临床安全用药提供参考。方法分析1例70岁男性患者使用碘佛醇注射液后出现肝酶持续性上升的案例,评价肝损伤与碘佛醇注射液的相关性,并通过文献回顾讨论造影剂引起肝损伤的情况及可能原因。结果关联性评价显示,本例患者发生严重肝损伤可能为碘佛醇注射液所致,通过保肝治疗,患者肝功能逐渐好转。结论碘佛醇注射液可能引起肝功能异常的不良反应,临床应关注碘佛醇注射液的不良反应风险,加强监测。Objective To analyze one case of hepatic injury caused by ioversol injection in order to provide a reference for clinical use.Methods The clinical data of a 70-year-old male patient who experienced persistent elevation of liver enzymes after receiving ioversol injection was analyzed.The correlations between hepatic injury and ioversol injection were studied,and a literature review was conducted to identify cases of contrast agent-induced hepatic injury and potential causes.Results Based on correlation assessment,the severe liver injury in this patient was believed to have been caused by administration of ioversol injection.The patient’s liver function gradually improved after hepatoprotective treatment.Conclusion Ioversol injection may cause adverse reactions that lead to hepatic dysfunction.Clinicians should be aware of the risk of adverse drug reactions associated with ioversol injection and enhance monitoring.

关 键 词：碘佛醇 注射液 造影剂 急性肝损伤 肝酶 药品不良反应 

分 类 号：R972.3[医药卫生—药品] R994.11[医药卫生—药学]