度拉糖肽对2型糖尿病合并肝硬化患者血糖水平、肝硬化指标的影响  

Effects of Dulaglutide on Blood Glucose Levels and Liver Cirrhosis Indexes in Patients with Type 2 Diabetes Mellitus Complicated with Liver Cirrhosis

作　　者：袁芝娴 赖龙斌 陈申 邓鹏 黄颖 YUAN Zhixian;LAI Longbin;CHEN Shen;DENG Peng;HUANG Ying(Department of Nephroendocrine,Ganzhou Fifth People's Hospital,Ganzhou 341000,China;不详)

机构地区：[1]赣州市第五人民医院肾内内分泌科,江西赣州341000 [2]赣州市第五人民医院精神科,江西赣州341000

出　　处：《中国医学创新》2025年第12期13-16,共4页Medical Innovation of China

基　　金：江西省卫生健康委科技计划项目(202511103)。

摘　　要：目的:分析度拉糖肽对2型糖尿病合并肝硬化患者血糖、肝硬化指标的影响。方法:选取2022年1—12月赣州市第五人民医院收治的2型糖尿病合并肝硬化患者80例为研究对象,采用随机抽签法将其分为对照组与观察组,各40例。对照组采用胰岛素治疗,观察组在对照组基础上给予度拉糖肽治疗。比较两组血糖、肝硬化指标。结果:治疗第30、90、180天及治疗1年后,观察组的空腹血糖(FBG)、餐后2 h血糖(2 h PBG)水平均低于对照组,差异均有统计学意义(P<0.05);治疗第180天及治疗1年后,观察组的肝硬度值(LSM)均低于对照组,差异均有统计学意义(P<0.05)。结论:度拉糖肽能改善2型糖尿病合并肝硬化患者的血糖水平与肝功能。Objective:To analyze the effects of Dulaglutide on blood glucose and liver cirrhosis indexes in patients with type 2 diabetes mellitus.Method:A total of 80 patients with type 2 diabetes mellitus complicated with liver cirrhosis admitted to Ganzhou Fifth People's Hospital from January to December 2022 were selected as the study objects,and they were divided into control group and observation group by random drawing method,with 40 cases in each group.The control group was treated with insulin,and the observation group was treated with Dulaglutide on the basis of the control group.Blood glucose and liver cirrhosis index were compared between the two groups.Result:On the 30th,90th and 180th days of treatment and 1 year after treatment,the fasting blood glucose(FBG)and 2 h postprandial blood glucose(2 h PBG)levels in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).On the 180th days of treatment and 1 year after treatment,the liver stiffness measurement(LSM)of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion:Dulaglutide can improve blood glucose levels and liver function in patients with type 2 diabetes mellitus complicated with liver cirrhosis.

关 键 词：度拉糖肽 2型糖尿病 肝硬化 血糖 肝硬度值 

分 类 号：R587.1[医药卫生—内分泌]