乙酰半胱氨酸雾化联合莫西沙星对重症肺炎患者血清炎症因子及氧合指数的影响  

Effects of Acetylcysteine Atomization Combined with Moxifloxacin on Serum Inflammatory Factors,Oxygenation Index in Patients with Severe Pneumonia

作　　者：周蓓 邱饶元 ZHOU Bei;QIU Raoyuan(Critical Care Medicine,Shangrao Central Hospital,Shangrao 334000,China;不详)

机构地区：[1]上饶市中心医院重症医学科,江西上饶334000 [2]上饶市中心医院呼吸内科,江西上饶334000

出　　处：《中国医学创新》2025年第12期107-110,共4页Medical Innovation of China

摘　　要：目的:探讨乙酰半胱氨酸雾化联合莫西沙星在重症肺炎患者中的治疗效果。方法:采用便利抽样法,选取2021年1月—2024年1月上饶市中心医院收治的80例重症肺炎患者,按随机数字表法分为两组,各40例。均采用常规治疗。对照组加用莫西沙星治疗,观察组在对照组基础上加用乙酰半胱氨酸雾化,持续治疗2周。对比两组治疗效果、血清炎症因子、血气分析指标、氧合指数、症状改善情况及安全性。结果:观察组总有效率为95.00%,高于对照组的80.00%,差异有统计学意义(P<0.05);治疗后,观察组C反应蛋白(CRP)为(10.35±1.38)mg/L,白细胞(WBC)计数为(9.51±1.10)×10^(9)/L,降钙素原(PCT)为(0.30±0.16)ng/mL,动脉血二氧化碳分压(PaCO_(2))为(41.57±3.65)mmHg,均低于对照组的(13.04±1.48)mg/L、(11.37±1.25)×10^(9)/L、(0.72±0.25)ng/mL、(46.74±3.26)mmHg;动脉血氧分压(PaO_(2))为(78.51±4.01)mmHg,动脉血氧饱和度(SaO_(2))为(95.56±1.37)%,氧合指数(OI)为(170.57±15.30)mmHg,均高于对照组的(72.67±4.45)mmHg、(93.04±1.29)%、(152.47±14.32)mmHg;发热改善时间为(4.27±0.34)d,咳嗽改善时间为(5.06±0.88)d,肺部啰音改善时间为(5.42±0.81)d,肺部阴影改善时间为(6.77±1.02)d,均早于对照组的(5.16±0.62)、(6.12±0.97)、(6.64±0.73)、(8.86±1.14)d,差异均有统计学意义(P<0.05)。两组均未发生不良反应。结论:乙酰半胱氨酸雾化联合莫西沙星可增强重症肺炎治疗效果,减轻炎症水平,改善氧合指数与血气分析指标,促进症状消退,安全可靠。Objective:To investigate the therapeutic effect of Acetylcysteine atomization combined with Moxifloxacin in patients with severe pneumonia.Method:A total of 80 patients with severe pneumonia admitted to Shangrao Central Hospital from January 2021 to January 2024 were selected by convenience sampling method and divided into two groups with 40 cases each according to random number table method.All patients were treated with conventional treatment.The control group was treated with Moxifloxacin,and the observation group was treated with Acetylcysteine atomization on the basis of the control group.Two groups were treated for 2 weeks.The therapeutic effect,serum inflammatory factors,blood gas analysis index,oxygenation index,symptom improvement and safety of the two groups were compared.Result:The total effective rate of the observation group was 95.00%,which was higher than 80.00%of the control group(P<0.05).After treatment,the C reactive protein(CRP)was(10.35±1.38)mg/L,the white blood cell(WBC)count was(9.51±1.10)×10^(9)/L,the procalcitonin(PCT)was(0.30±0.16)ng/mL,the arterial partial pressure of carbon dioxide(PaCO_(2))was(41.57±3.65)mmHg of the observation group,which were lower than(13.04±1.48)mg/L,(11.37±1.25)×10^(9)/L,(0.72±0.25)ng/mL,(46.74±3.26)mmHg of control group;arterial partial oxygen pressure(PaO_(2))was(78.51±4.01)mmHg,blood oxygen saturation(SaO_(2))was(95.56±1.37)%,oxygenation index(OI)was(170.57±15.30)mmHg of the observation group,which were higher than(72.67±4.45)mmHg,(93.04±1.29)%,(152.47±14.32)mmHg of the control group;fever improvement time was(4.27±0.34)d,cough improvement time was(5.06±0.88)d,lung rale improvement time was(5.42±0.81)d,lung shadow improvement time was(6.77±1.02)d in the observation group,which were shorter than(5.16±0.62),(6.12±0.97),(6.64±0.73),(8.86±1.14)d in the control group,the differences were statistically significant(P<0.05).No adverse reactions occurred in the two groups.Conclusion:Acetylcysteine atomization combined with Moxifloxacin can enhanc

关 键 词：重症肺炎 乙酰半胱氨酸 莫西沙星 血清炎症因子 氧合指数 

分 类 号：R563.1[医药卫生—呼吸系统]