小儿复方磺胺甲噁唑与阿奇霉素治疗小儿百日咳的临床效果及安全性对比  

Comparison of Clinical Efficacy and Safety of Pediatric Compound Sulfamethoxazole and Azithromycin in the Treatment of Pertussis in Children

作　　者：肖九发 王锦兰 XIAO Jiufa;WANG Jinlan(Department of Pediatrics,Affiliated Yudu Hospital of Gannan Medical University,Yudu 342300,China;不详)

机构地区：[1]赣南医科大学附属于都医院儿科,江西于都342300 [2]赣南医科大学附属于都医院药剂科,江西于都342300

出　　处：《中国医学创新》2025年第12期135-140,共6页Medical Innovation of China

基　　金：江西省中医药管理局科技计划项目(2022A523)。

摘　　要：目的:对比分析小儿复方磺胺甲噁唑与阿奇霉素治疗小儿百日咳的临床效果及安全性。方法:收集2021年1月—2024年1月赣南医科大学附属于都医院118例小儿百日咳患儿进行前瞻性研究,随机分为试验组(59例)与对照组(59例)。对照组接受阿奇霉素治疗,试验组接受小儿复方磺胺甲噁唑治疗。比较两组的临床效果、临床症状消失时间、血常规指标[白细胞计数(WBC)、淋巴细胞百分比(LYM%)、血小板计数(PLT)]、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)、白细胞介素-8(IL-8)]、不良反应发生率、住院时间。结果:试验组总有效率为93.22%(55/59),高于对照组的79.66%(47/59),差异有统计学意义(P<0.05)。与对照组比较,试验组发热、肺部啰音、气促、痉挛性咳嗽消失时间均较早,差异均有统计学意义(P<0.05)。与对照组比较,治疗后试验组WBC、LYM%、PLT均较低,差异均有统计学意义(P<0.05)。与对照组比较,治疗后试验组TNF-α、IL-4、IL-8水平均较低,差异均有统计学意义(P<0.05)。试验组不良反应发生率为8.47%(5/59),低于对照组的22.03%(13/59),差异有统计学意义(P<0.05)。与对照组比较,试验组住院时间较短,差异有统计学意义(P<0.05)。结论:与阿奇霉素相比,小儿复方磺胺甲噁唑治疗小儿百日咳效果更好,能减轻炎症反应,可改善临床症状和血常规,且不良反应发生率较低,能加快患儿恢复,缩短住院时间。Objective:To compare and analyze the clinical efficacy and safety of Pediatric Compound Sulfamethoxazole and Azithromycin in the treatment of pertussis in children.Method:A prospective study was conducted on 118 children with pertussis from January 2021 to January 2024 in Affiliated Yudu Hospital of Gannan Medical University.They were randomly divided into an experimental group(59 cases)and a control group(59 cases).The control group received Azithromycin treatment,while the experimental group received Compound Sulfamethoxazole treatment.The clinical effect,disappearance time of clinical symptoms,blood routine indicators[white blood cell count(WBC),percentage of lymphocytes(LYM%),platelet count(PLT)],inflammatory factor[tumor necrosis factor-α(TNF-α),interleukin-4(IL-4),interleukin-8(IL-8)],incidence of adverse reactions,and length of hospital stay were compared between the two groups.Result:The total effective rate of the experimental group was 93.22%(55/59),which was higher than 79.66%(47/59)in the control group,the difference was statistically significant(P<0.05).Compared with the control group,the experimental group had earlier disappearance time for fever,lung rales,shortness of breath,and spasmodic cough,the differences were statistically significant(P<0.05).After treatment,compared with the control group,the experimental group had lower WBC,LYM%,and PLT,the differences were statistically significant(P<0.05).After treatment,compared with the control group,the experimental group had lower levels of TNF-α,IL-4,and IL-8,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 8.47%(5/59),which was lower than 22.03%(13/59)in the control group,the difference was statistically significant(P<0.05).Compared with the control group,the experimental group had a shorter hospital stay,the difference was statistically significant(P<0.05).Conclusion:Compared with Azithromycin,Pediatric Compound Sulfamethoxazole is more effective in the treatment of pertussi

关 键 词：小儿 百日咳 小儿复方磺胺甲噁唑 阿奇霉素 

分 类 号：R725.6[医药卫生—儿科]