NLR、PLR、RDW联合IL-6在AECOPD预后不良中的意义及其预测效能分析  

Significance of NLR,PLR,RDW Combined with IL-6 in Poor Prognosis of AECOPD and Its Predictive Efficacy Analysis

作　　者：陈招娣 游建华 谢文琦 CHEN Zhaodi;YOU Jianhua;XIE Wenqi(Department of Clinical Laboratory,First People's Hospital of Fuzhou,Fuzhou 344000,China;不详)

机构地区：[1]抚州市第一人民医院检验科,江西抚州344000

出　　处：《中国医学创新》2025年第12期144-148,共5页Medical Innovation of China

基　　金：抚州市社会发展指导性科技计划项目(抚科社字〔2024〕1号第8项)。

摘　　要：目的:分析中性粒细胞/淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、血小板/淋巴细胞比值(platelet-to-lymphocyte ratio,PLR)、红细胞体积分布宽度(red cell volume distribution width,RDW)联合白介素-6(interleukin-6,IL-6)在慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)预后不良中的预测价值。方法:选取抚州市第一人民医院收治的AECOPD患者50例为研究对象,时间为2022年6月—2024年6月。采集所有患者静脉血标本对中性粒细胞、淋巴细胞、血小板、RDW及IL-6水平进行检测,计算NLR、PLR,并分析NLR、PLR、RDW联合IL-6在AECOPD预后不良中的预测价值。结果:50例AECOPD患者中,存活39例,存活率为78.00%。与死亡组相比,存活组NLR、PLR、RDW、IL-6水平及吸烟史占比均低,年龄小,差异均有统计学意义(P<0.05)。logistic回归分析结果显示,NLR、PLR、RDW、IL-6、年龄及吸烟史均为AECOPD预后不良的影响因素(P<0.05)。NLR、PLR、RDW、IL-6单独预测AECOPD预后不良的曲线下面积(AUC)分别为0.660、0.765、0.618、0.697;NLR、PLR、RDW、IL-6联合预测AECOPD预后不良的AUC、敏感度、特异度分别为0.810、81.56%、84.24%。结论:NLR、PLR、RDW、IL-6、年龄及吸烟史均为AECOPD预后不良的影响因素,NLR、PLR、RDW联合IL-6预测AECOPD预后不良的效能高。Objective:To analyze the predictive value of neutrophil-to-lymphocyte ratio(NLR),plateletto-lymphocyte ratio(PLR),red cell volume distribution width(RDW)combined with interleukin-6(IL-6)in poor prognosis of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Method:A total of 50 patients with AECOPD treated in the First People's Hospital of Fuzhou from June 2022 to June 2024 were selected as the study objects.The venous blood samples of all patients were collected,the levels of neutrophil,lymphocyte,platelet,RDW and IL-6 were detected,NLR and PLR were calculated,and the predictive value of NLR,PLR,RDW combined with IL-6 in the poor prognosis of AECOPD were analyzed.Result:Among the 50 patients with AECOPD,39 survived,with a survival rate of 78.00%.Compared with the death group,the levels of NLR,PLR,RDW,IL-6 and proportion of smoking history in the survival group were lower,and the age was young,the differences were statistically significant(P<0.05).logistic regression analysis showed that NLR,PLR,RDW,IL-6,age and smoking history were all influencing factors for the poor prognosis of AECOPD(P<0.05).The area under the curve(AUC)of NLR,PLR,RDW and IL-6 in predicting poor prognosis of AECOPD were 0.660,0.765,0.618 and 0.697,respectively.The AUC,sensitivity and specificity of the combination of NLR,PLR,RDW and IL-6 in predicting the poor prognosis of AECOPD were 0.810,81.56%and 84.24%,respectively.Conclusion:NLR,PLR,RDW,IL-6,age and smoking history are all influencing factors for the poor prognosis of AECOPD,and NLR,PLR,RDW combined with IL-6 has high efficacy in predicting the poor prognosis of AECOPD.

关 键 词：中性粒细胞/ 淋巴细胞比值 血小板/ 淋巴细胞比值 红细胞体积分布宽度 白介素-6 慢性阻塞性肺疾病急性加重期 预后不良 

分 类 号：R563[医药卫生—呼吸系统]