基于“脾肾阳虚,痰浊阻滞”理论探讨神经根型颈椎病与线粒体自噬的关系  

Exploring the Relationship between Cervical Spondylotic Radiculopathy and Mitophagy Based on the Theory of"Yang Deficiency of Spleen and Kidney,Blockade of Phlegm-Turbidity"

作　　者：王悦 董平 姚广源 胡凯 WANG Yue;DONG Ping;YAO Guangyuan;HU Kai(College of Traditional Chinese Medicine,Inner Mongolia Medical University,Hohhot 010110,China;不详)

机构地区：[1]内蒙古医科大学中医学院,内蒙古呼和浩特010110

出　　处：《中国医学创新》2025年第12期180-184,共5页Medical Innovation of China

基　　金：内蒙古自治区自然科学基金项目(2022QN08010);内蒙古自治区卫生健康科技计划项目(202201193)。

摘　　要：神经根型颈椎病的发病机制、治疗是目前医学研究的热点。线粒体自噬是指清除或降解受损、老化线粒体的方式。线粒体自噬在椎间盘退行性病变、神经病理性疼痛的发生发展中都发挥了重要作用,而椎间盘退行性病变及神经病理性疼痛都与神经根型颈椎病息息相关,因此推断线粒体自噬与神经根型颈椎病的发病密切相关。中医认为,神经根型颈椎病的主要病机为脾肾阳虚,痰浊阻滞,这与线粒体自噬在微观层面有相似之处。因此本文将基于“脾肾阳虚,痰浊阻滞”理论从中、西医角度探讨线粒体自噬与神经根型颈椎病的关系,为神经根型颈椎病的研究与治疗提供新的方向与靶点。The pathogenesis and treatment of cervical spondylotic radiculopathy are the focus of medical research at present.Mitophagy is the process of removing or degrading damaged and aged mitochondrion.Mitophagy plays an important role in the occurrence and development of intervertebral disc degenerative change and neuropathic pain,and both intervertebral disc degenerative change and neuropathic pain are closely related to cervical spondylotic radiculopathy,so it is inferred that mitophagy is closely related to the onset of cervical spondylotic radiculopathy.According to traditional Chinese medicine,the main pathogenesis of cervical spondylotic radiculopathy is yang deficiency of spleen and kidney and blockade of phlegm-turbidity,which is similar to mitophagy at the microscopic level.Therefore,based on the theory of"Yang deficiency of spleen and kidney,blockade of phlegm-turbidity",this paper will explore the relationship between mitophagy and cervical spondylotic radiculopathy from the perspective of traditional Chinese medicine and western medicine,providing a new direction and target for the research and treatment of cervical spondylotic radiculopathy.

关 键 词：神经根型颈椎病 脾肾阳虚 痰浊阻滞 线粒体自噬 

分 类 号：R274.9[医药卫生—中西医结合]