PCI灌注前应用β受体阻滞剂对急性心肌梗死患者的影响  

Effect ofβ-receptor Blocker before PCI Perfusion in Patients with Acute Myocardial Infarction

作　　者：曹晴 CAO Qing(Jiangsu Province(Suqian)Hospital,Suqian 223800,China)

机构地区：[1]江苏省人民医院宿迁医院,江苏宿迁223800

出　　处：《中外医学研究》2025年第10期28-31,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析急性心肌梗死(AMI)患者行经皮冠状动脉介入治疗(PCI)灌注前应用β受体阻滞剂的效果。方法:选取2022年4月—2024年4月江苏省人民医院宿迁医院收治的101例AMI患者资料,根据治疗方法不同分为对照组(n=50)和观察组(n=51)。两组均进行标准PCI治疗流程,观察组于PCI灌注前给予β受体阻滞剂(盐酸艾司洛尔)治疗,对照组用生理盐水作为安慰剂。比较两组患者手术前后心肌损伤标志物水平、心功能,并统计两组患者主要心血管不良事件(MACE)及心脏破裂发生率。结果:术后1周,观察组患者肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)及N端钠尿肽前体(NT-proBNP)水平明显低于对照组,差异有统计学意义(P<0.05);术后1周,观察组患者左室射血分数(LVEF)及左室短轴缩短率(LVFS)水平均高于对照组,差异有统计学意义(P<0.05);术后6个月内,观察组患者MACE发生率低于对照组,差异有统计学意义(P<0.05);观察组无心脏破裂发生,对照组有1例发生心脏破裂,两组比较差异无统计学意义(P>0.05)。结论:AMI患者行PCI术前应用β受体阻滞剂治疗可改善患者心脏功能,降低心肌损伤标志物水平及MACE发生率。Objective:To analyze the effect ofβ-receptor blocker before percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI).Method:A total of 101 patients with AMI admitted to the Jiangsu Province(Suqian)Hospital from April 2022 to April 2024 were selected and divided into control group(n=50)and observation group(n=51)according to different treatment methods.Both teams underwent standard PCI treatment protocol,with the observation group receivingβ-receptor blocker(Esolol Hydrochloride)treatment before PCI infusion,and the control team receiving Physiological Saline as a placebo.The levels of cardiac damage markers and cardiac function between two groups of patients before and after surgery,and calculate the incidence of major cardiovascular adverse events(MACE)and cardiac rupture in both groups of patients were compared.Result:At 1 week after surgery,the levels of creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTnI)and n-terminal natriuretic peptide precursor(NT-proBNP)in observation group were significantly lower than those in control group,the differences were statistically significant(P<0.05).At 1 week after surgery,left ventricular ejection fraction(LVEF)and left ventricular short axis shortening rate(LVFS)in observation group were higher than those in control group,the differences were statistically significant(P<0.05).Within 6 months after surgery,the incidence of MACE in observation group was lower than that in control group,the difference was statistically significant(P<0.05).There was no cardiac rupture in the observation group and 1 case in the control group,and there was no statistical significance between the two groups(P>0.05).Conclusion:The use ofβ-receptor blocker before PCI in patients with AMI can improve the cardiac function,reduce the level of myocardial injury markers and the occurrence of MACE.

关 键 词：急性心肌梗死 经皮冠状动脉介入治疗 Β受体阻滞剂 心脏破裂 

分 类 号：R541.4[医药卫生—心血管疾病]