非洲猪瘟基因Ⅰ/Ⅱ型重组病毒疫苗研究进展  

Advances in Vaccines against African Swine Fever Genotypes Ⅰ and Ⅱ Recombinant Viruses

作　　者：戈胜强[1,2,3] 吕艳 左媛媛[1] 于家荣[1] 殷磊 韩秀琚 王筱真[1] 刘珊 郑辉[1] 王晓华[1] 李金明[1] 魏荣[1] 王志亮[1] Ge Shengqiang;Lu Yan;Zuo Yuanyuan;Yu Jiarong;Yin Lei;Han Xiuju;Wang Xiaozhen;Liu Shan;Zheng Hui;Wang Xiaohua;Li Jinming;Wei Rong;Wang Zhiliang(China Animal Health and Epidemiology Center,Qingdao 266032,Shandong,China;Qingdao Key Laboratory of Modem Bioengineering and Animal Disease Research,Qingdao 266032,Shandong,China;Key Laboratory of Animal Biosafety Risk Waring Prevention and Control(South China),Ministry of Agriculture and Rural Affairs,Qingdao 266032,Shandong,China;Qingdao Agricultural University,Qingdao 266109,Shandong,China)

机构地区：[1]中国动物卫生与流行病学中心,山东青岛266032 [2]青岛市现代生物工程及动物疫病研究重点实验室,山东青岛266032 [3]农业农村部动物生物安全风险预警及防控重点实验室(南方),山东青岛266032 [4]青岛农业大学,山东青岛266109

出　　处：《中国动物检疫》2025年第3期72-76,共5页China Animal Health Inspection

基　　金：国家重点研发计划项目(2022YFD1800500)。

摘　　要：非洲猪瘟病毒(ASFV)重组事件在临床中并不是偶然现象,它是造成ASFV遗传多样性的原因之一,但是以基因Ⅰ型和基因Ⅱ型为母本病毒,发生“嵌合式重组”尚属首次发现。目前,对于中国、越南和俄罗斯报道的重组毒均已开展过攻毒试验,证实重组毒致病力较强且同居感染能力较强。同时中国和越南实验室均对重组毒进行了在研/在售疫苗的攻毒保护评价,证实基因Ⅱ型弱毒疫苗不能抵御重组毒攻击,这对ASFV重组病毒疫苗研究提出了新的挑战。本文通过总结已发表的ASFV重组毒动物实验数据,进一步分析该病毒感染特点,总结该病毒疫苗研究进展,以期为国内相关研究和防控措施制定提供参考。Recombination of African swine fever virus(ASFV),as one of the reasons for the genetic diversity of the virus,was not accidental in clinical practice,but it was the first time that“chimeric recombination”occurred with genotypesⅠandⅡas the parent viruses.Recombinant viruses reported by China,Vietnam and Russia were challenged,confirming their strong virulence and cohabitation infectivity.Meanwhile,the protective efficiency of vaccines under development and those on sale against the recombinant viruses were evaluated by laboratories in both China and Vietnam,confirming that attenuated vaccines against genotypeⅡviruses failed to defend against the attack by recombinant viruses,and posing a new challenge to the research on vaccines against ASFV recombinant viruses.Here,published data of recombinant ASFV in animal experiments was summarized,the characteristics of the virus infection were analyzed,and the advances of researches on the vaccines were reviewed,with a view to providing a reference for relevant researches and development of preventive and control measures in China.

关 键 词：非洲猪瘟 重组病毒 疫苗研发 

分 类 号：S852.65[农业科学—基础兽医学]