OSAS暂停合并COPD患者中CRP表达水平和RDW变化与AHI、ODI、LSaO_(2)的相关性研究  

The correlation between CRP expression levels and RDW changes with AHI,ODI,and LSaO_(2) in OSAHS patients complicated with COPD

作　　者：王正龙 陈文燕 高涛 付瑜 WANG Zhenglong;CHEN Wenyan;GAO Tao;FU Yu(Department of Respiratory Medicine,Yiwu Fuyuan Private Hospital,Yiwu Zhejiang Province,322000,China)

机构地区：[1]浙江义乌復元私立医院呼吸二科,义乌322000 [2]浙江义乌復元私立医院五官科,义乌322000

出　　处：《中国中西医结合耳鼻咽喉科杂志》2025年第2期115-118,88,共5页Chinese Journal of Otorhinolaryngology in Integrative Medicine

摘　　要：目的探讨睡眠呼吸暂停综合征(OSAS)合并慢性阻塞性肺病(COPD)患者中C反应蛋白(CRP)和红细胞分布宽度(RDW)水平的变化及其与AHI、ODI、LSaO_(2)的相关性。方法本研究纳入我院35例OSAS合并COPD患者和35名对照对象。使用多导睡眠监测评估患者的AHI、ODI和LSaO_(2),并测定血清CRP和RDW水平。结果观察组患者的CRP和RDW水平显著高于对照组(P<0.001)。CRP和RDW与AHI、ODI呈显著正相关,与LSaO_(2)呈显著负相关(P<0.001)。结论CRP和RDW可作为评估OSAS合并COPD患者病情有效生物标志物,有助于早期识别高风险患者并指导临床干预。Objective To investigate the changes in C-reactive protein(CRP)and red cell distribution width(RDW)levels in patients with obstructive sleep apnea syndrome(OSAS)combined with chronic obstructive pulmonary disease(COPD)and their correlation with AHI、ODI、LSaO_(2).Methods This study included 35 patients with OSAS combined with COPD and 35 healthy volunteers from our hospital.Polysomnography was used to assess patients'AHI,ODI,and LSaO_(2),and serum CRP and RDW levels were measured.Results CRP and RDW levels in the observation group were significantly higher than those in the control group(P<0.001).CRP and RDW were significantly positively correlated with AHI and ODI and negatively correlated with LSaO_(2)(P<0.001).Conclusions CRP and RDW can serve as effective biomarkers for assessing the severity of disease in patients with OSAS combined with COPD,aiding in the early identification of high-risk patients and guiding clinical interventions.

关 键 词：炎症标志物 慢性低氧血症 红细胞分布宽度 

分 类 号：R563.9[医药卫生—呼吸系统]