静脉用硫酸镁改善术后睡眠质量的有效性和安全性:一项系统评价和荟萃分析  

Efficacy and safety of intravenous magnesium sulfate in improving postoperative sleep quality:a systematic review and meta-analysis

作　　者：莫杏樱 张婧婷 张振业 朱茜茜 周少丽[1] MO Xingying;ZHANG Jingting;ZHANG Zhenye;ZHU Qianqian;ZHOU Shaoli(Surgical Anesthesia Center,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China;Department of Anesthesiology,the Seventh Affiliated Hospital of Sun Yat-sen University,Shenzhen 518107,China)

机构地区：[1]中山大学附属第三医院手术麻醉中心,广东广州510630 [2]中山大学附属第七医院麻醉科,广东深圳518107

出　　处：《新医学》2025年第4期386-394,共9页Journal of New Medicine

基　　金：广东省医学会研究基金(2022375);广东省医院药学研究基金(2020XC06)。

摘　　要：目的 系统评价静脉用硫酸镁改善术后睡眠质量的有效性和安全性。方法 计算机检索PubMed、Web of Science、Embase、Cochrane Library、中国知网、万方数据库、维普数据库和灰色数据库中关于静脉用硫酸镁改善术后睡眠质量的临床随机对照试验,检索时间从建库起至2024年3月,纳入文献在质量学评价后,用RevMan 5.4软件进行荟萃分析。结果 纳入5项研究共256例手术患者。荟萃分析结果显示,围术期静脉用硫酸镁患者术后第1晚睡眠质量的视觉模拟评分法(VAS)评分(均数差为-1.49,95%CI-1.87~-1.12,P <0.000 01)优于对照组,且2组术后运动状态下的疼痛VAS评分以及恶心呕吐、寒战、低血压等安全性结局无显著性差异(均P> 0.05)。结论 围术期静脉用硫酸镁可以改善患者术后睡眠质量,且未发生严重不良反应,患者可从中获益。Objective To systematically evaluate the efficacy and safety of intravenous magnesium sulfate in improving postoperative sleep quality.Methods Clinical randomized controlled trials assessing the role of intravenous magnesium sulfate in improving postoperative sleep quality were searched from PubMed,Web of Science,Embase,Cochrane Library,CNKI,Wanfang,VIP Database,and Grey Literature Database.The retrieval time was from the date of database inception to March 2024.The included literatures were subject to meta-analysis using RevMan 5.4 software after quality evaluation.Results A total of 256 surgical patients from five studies were included.The results of meta-analysis showed that the Visual Analogue Scale(VAS)score(mean difference was-1.49,95%CI‒1.87~-1.12,P<0.00001)of sleep quality in the first night in patients receiving perioperative intravenous magnesium sulfate was better than that in the control group,and there were no significant differences in postoperative VAS pain scores under activity status,and the outcomes of nausea and vomiting,shivering and hypotension between two groups(all P>0.05).Conclusion Intravenous magnesium sulfate during perioperative period can improve postoperative sleep quality and bring clinical benefits to patients without severe adverse reactions.

关 键 词：硫酸镁 睡眠质量 静脉用药 系统评价 荟萃分析 

分 类 号：R614[医药卫生—麻醉学]