烟碱来源判别方法研究进展  

Research progress on identification methods of nicotine sources

作　　者：何莺 卢乐华 李晓楠 金银换 高峄涵 邱立欢 HE Ying;LU Lehua;LI Xiaonan;JIN Yinhuan;GAO Yihan;QIU Lihuan(Shanghai New Tobacco Products Research Institute Co.,Ltd.,Shanghai 201315,China)

机构地区：[1]上海新型烟草制品研究院有限公司,上海市浦东新区秀浦路3733号201315

出　　处：《中国烟草学报》2025年第2期156-166,共11页Acta Tabacaria Sinica

基　　金：中国烟草总公司科技重大专项(110202202019);上海新型烟草制品研究院有限公司科研项目(K2023-006Z)。

摘　　要：天然烟碱和合成烟碱的感官体验及药理作用不同,判别烟碱来源可为烟碱的使用安全和质量保障提供方法学支撑。本文基于天然烟碱和合成烟碱在对映异构体比例、次级生物碱、同位素比值方面的差异,综述了烟碱对映异构体判别法、次级生物碱判别法和同位素判别法3类判别烟碱来源的方法,概述了3类方法的优势与挑战,并讨论了3类方法的适用范围。最后,提出推荐流程,为烟碱来源判别方法的开发与应用提供理论参考。The sensory experience and pharmacological effects of natural nicotine and synthetic nicotine differ.Identifyin the source of nicotine can provide methodological support for the safety and quality assurance of nicotine use.Based on the differences between natural and synthetic nicotine in terms of nicotinic enantiomer ratio,minor tobacco alkaloids,and isotope ratio,this paper reviews three types of methods to identify the source of nicotine,namely,nicotinic enantiomer identification,minor tobacco alkaloid identification,and isotope identification.It summarizes the advantages and challenges of these three methods and discusses their applicable scopes.Finally,a recommended process is proposed to provide theoretical reference for the development and application of nicotine source identification methods.

关 键 词：烟碱来源 对映异构体 次级生物碱 同位素 判别方法 

分 类 号：R284.1[医药卫生—中药学] R284[医药卫生—中医学]