地塞米松棕榈酸酯分子结构中红外/变温中红外光谱  

Study on the mid-infrared/temperature dependent infrared spectroscopy of dexamethasone palmitate molecular structure

作　　者：李穆婵 柴嘉欣 吉一帆 雷晓静 徐元媛 于宏伟[1,3] Li Muchan;Chai Jiaxin;Ji Yifan;Lei Xiaojing;Xu Yuanyuan;Yu Hongwei(Shijiazhuang University College of Chemical Technology;Hebei University of Science&Technology School of Chemical and Pharmaceutical Engineering;Anesthetic Technology Innovation Center of Hebei Province)

机构地区：[1]石家庄学院化工学院 [2]河北科技大学 [3]河北省麻醉药技术创新中心

出　　处：《上海计量测试》2025年第1期39-45,共7页Shanghai Measurement and Testing

摘　　要：探究了地塞米松棕榈酸酯分子结构及热变性研究。分别开展地塞米松棕榈酸酯分子结构中红外(MIR)光谱及变温MIR光谱实验。结果发现:地塞米松棕榈酸酯分子结构的红外吸收模式主要为:ν_(O-H)(包括:ν_(O-H-游离)、ν_(O-H-二聚体)、ν_(O-H-多聚体)、ν_(asCH_(2))、ν_(sCH_(2))、ν_(C=O)(包括:ν_(C=O-1)和ν_(C=O-2))、ν_(C=C)(包括:ν_(C=C-1)、ν_(C=C-2)和ν_(C=C-3))、δ_(CH_(2))、δ_(asCH_(3))、δ_(sCH_(3))、ν_(C-O)/ν_(C-F)(包括:ν_(C-O-1)/ν_(C-F-1)、ν_(C-O-2)/ν_(C-F-2)、ν_(C-O-3)/ν_(C-F-3)、ν_(C-O-4)/ν_(C-F-4)和ν_(C-O-5)/ν_(C-F-5))和ρ_(CH_(2))。在热扰动因素下,地塞米松棕榈酸酯分子结构由晶体态转变为熔融态,其主要官能团对应的吸收频率及强度均有明显的改变,其中333~338 K是一个临界温度区间。MIR/变温MIR光谱开展地塞米松棕榈酸酯分子结构及热变性研究,具有重要的应用研究价值。This project explores the molecular structure and thermal denaturation of dexamethasone palmitate.This project conducts mid-infrared(MIR)spectroscopy and temperature dependent MIR spectroscopy experiments on the molecular structure of dexamethasone palmitate.The results showed that the infrared absorption modes of dexamethasone palmitate molecular structure mainly includeν_(OH)(includingν_(OH-free),ν_(OH-dimer),ν_(OH-polymer)),ν_(asCH_(2)),ν_(sCH_(2)),ν_(C=O)(includingν_(C=O-1)andν_(C=O-2)),ν_(C=C)(includingν_(C=C-1),ν_(C=C-2),andν_(C=C-3)),δ_(CH_(2)),δ_(asCH_(3)),δ_(sCH_(3)),ν_(C-O)/ν_(C-F)(includingν_(C-O-1)/ν_(C-F-1),ν_(C-O-2)/ν_(C-F-2),ν_(C-O-3)/ν_(C-F-3),ν_(C-O-4)/ν_(C-F-4),andν_(C-O-5)/ν_(C-F-5)),andρ_(CH_(2)).Under thermal disturbance,the molecular structure of dexamethasone palmitate changes from crystalline to molten state,and the absorption frequency and intensity corresponding to its main functional groups undergo significant changes.The critical temperature range is 333~338 K.The MIR/variable temperature MIR spectroscopy has important application research value in studying the molecular structure and thermal denaturation of dexamethasone palmitate.

关 键 词：地塞米松棕榈酸酯 中红外光谱 变温中红外光谱 结构 热变性 

分 类 号：O657.3[理学—分析化学]