CRP联合心肌酶谱及肝功能测定对轮状病毒感染性腹泻患儿的诊断价值  

Diagnostic Value of CRP Combined with Myocardial Enzyme Spectrum and Liver Function Tests in Children with Rotavirus-Infected Diarrhea

作　　者：程诚[1] CHENG Cheng(Children's Hospital Affiliated to Zhengzhou University/Children's Hospital of Henan Province/Zhengzhou Children's Hospital,Zhengzhou,Henan 450000,China)

机构地区：[1]郑州大学附属儿童医院/河南省儿童医院/郑州儿童医院,河南郑州450000

出　　处：《黔南民族医专学报》2025年第1期22-26,共5页Journal of Qiannan Medical College for Nationalities

摘　　要：目的:分析C反应蛋白(C-reactive protein,CRP)联合心肌酶谱及肝功能测定对小儿轮状病毒感染性腹泻患儿的诊断价值。方法:研究选取某院收治的36例轮状病毒感染患儿为观察组,另以同一时间进行体检的36例健康儿童为对照组;对比两组受试儿童CRP、心肌酶谱以及肝功能指标的检出阳性率,将轮状病毒抗原检测结果定为金标准,比较诊断价值。结果:观察组中CRP、肌酸激酶同工酶(CK-MB)的阳性检出率为100.00%,谷草转氨酶(AST)的阳性检出率为97.22%,谷丙转氨酶(ALT)的阳性检出率为94.44%,均高于对照组,组间对比差异提示有统计学意义(P<0.05)。组间CRP、CK-MB、ALT、AST对比差异显著(P<0.05),将大便轮状病毒感染抗原检测结果作为金标准,CRP、CK-MB、AST、ALT以及联合检测中联合检测的敏感度和特异度最高。ROC曲线分析结果显示,联合指标的曲线下面积(AUC)为1.000,高于单一指标检测的水平。结论:针对小儿轮状病感染性腹泻患儿实施CRP联合心肌酶谱及肝功能测定,能够显著提升临床对该病感染的灵敏度以及特异度,对患儿的预后评估具有辅助作用。Objective:To analyze the diagnostic value of C-reactive protein(CRP)combined with myocardial enzyme spectrum and liver function tests in children with rotavirus-infected diarrhea.Methods:This study included 36 children with rotavirus infection admitted to a hospital as the observation group and 36 healthy children undergoing physical examinations during the same period as the control group.The positive detection rates of CRP,myocardial enzyme spectrum,and liver function indicators were compared between the two groups.The diagnostic value was assessed with rotavirus antigen test results as the gold standard.Results:In the observation group,the positive detection rates of CRP and creatine kinase isoenzyme MB(CK-MB)were 100.00%,and the positive detection rates of aspartate aminotransferase(AST)and alanine aminotransferase(ALT)were 97.22%and 94.44%,respectively,all higher than those in the control group.The differences between the groups were statistically significant(P<0.05).Significant differences were observed in CRP,CK-MB,ALT,and AST levels between the groups(P<0.05).When the rotavirus antigen test in stool was used as the gold standard,the combined detection of CRP,CK-MB,AST,and ALT showed the highest sensitivity and specificity.ROC curve analysis revealed that the area under the curve(AUC)for the combined indicators was 1.000,higher than that for single indicator tests.Conclusion:The use of CRP combined with myocardial enzyme spectrum and liver function tests in children with rotavirus-infected diarrhea can significantly improve the clinical sensitivity and specificity of the diagnosis,aiding in the prognosis assessment of the patients.

关 键 词：C反应蛋白 心肌酶谱 肝功能 轮状病毒 腹泻 诊断效能 

分 类 号：R446[医药卫生—诊断学]