血清CTRP3、PPARγ水平与妊娠期糖尿病病人妊娠结局的关系  

Relationship between the serum levels of CTRP3 and PPARγand pregnancy outcome in patients with gestational diabetes mellitus

作　　者：吴丹 杨洋 辛慧 蔡凤 邓新 张丽丽 王丹 WU Dan;YANG Yang;XIN Hui;CAI Feng;DENG Xin;ZHANG Lili;WANG Dan(Department of Endocrinology and Metabolism,The Third Affiliated Hospital of Shenyang Medical College,Shenyang 242 Hospital,Liaoning Shenyang 110034,China;Department of Nursing,The Third Affiliated Hospital of Shenyang Medical College,Shenyang 242 Hospital,Liaoning Shenyang 110034,China)

机构地区：[1]沈阳医学院附属第三医院,沈阳二四二医院内分泌与代谢病科,辽宁沈阳110034 [2]沈阳医学院附属第三医院,沈阳二四二医院护理部,辽宁沈阳110034

出　　处：《蚌埠医科大学学报》2025年第3期304-308,共5页Journal of Bengbu Medical University

基　　金：辽宁省科学技术计划项目(2019-ZD-0875);沈阳市卫生健康委员会科研项目(2021099)。

摘　　要：目的:探讨妊娠期糖尿病(GDM)病人血清C1q/TNF相关蛋白3(CTRP3)、过氧化物酶体增殖物激活受体γ(PPARγ)水平与妊娠结局的关系。方法:选取GDM病人116例为GDM组,根据妊娠不良结局将其分为良好妊娠结局组78例和不良妊娠结局组38例。收集24周糖耐量试验正常的93例正常孕产妇作为对照组。采用酶联免疫吸附法检测血清CTRP3、PPARγ水平;Pearson相关性分析不良妊娠结局GDM病人血清CTRP3、PPARγ水平与FPG、HbA1c的相关性;ROC曲线分析血清CTRP3、PPARγ水平对GDM病人不良妊娠结局的预测价值;logistic回归分析GDM病人不良妊娠结局的影响因素。结果:与对照组比较,GDM组血清CTRP3、PPARγ水平明显降低(P<0.01),不良妊娠结局总发生率明显升高(P<0.01)。与良好妊娠结局组比较,不良妊娠结局组FPG、HbA1c明显升高(P<0.01),血清CTRP3、PPARγ水平明显降低(P<0.01)。不良妊娠结局GDM病人血清CTRP3、PPARγ水平与FPG、HbA1c水平均呈负相关关系(P<0.05)。血清CTRP3、PPARγ水平及联合预测GDM病人不良妊娠结局的AUC分别为0.747、0.844、0.901。CTRP3、PPARγ是GDM病人发生不良妊娠结局的保护因素(P<0.01)。结论:GDM病人血清CTRP3、PPARγ水平与不良妊娠结局有关,二者对预测GDM病人不良妊娠结局均有一定的价值。Objective:To investigate the relationship between the serum levels of C1q/TNF related protein 3(CTRP3)and peroxisome proliferator activated receptorγ(PPARγ)and pregnancy outcome in patients with gestational diabetes mellitus(GDM).Methods:One hundred and sixteen GDM patients were selected as the GDM group,and subdivided into the good pregnancy outcome group(78 cases)and adverse pregnancy outcome group(38 cases)according to the adverse pregnancy outcome.Ninety-three normal pregnant women with normal glucose tolerance test at 24 weeks were collected as the control group.The serum levels of CTRP3 and PPARγwere detected by enzyme linked immunosorbent assay.The Pearson correlation was used to analyze the correlation between the serum levels of CTRP3 and PPARγ,and levels of FPG and HbA1c in GDM patients with adverse pregnancy outcomes.The ROC curve was used to analyze the predictive value of serum levels of CTRP3 and PPARγfor adverse pregnancy outcomes in GDM patients.Logistic regression analysis was used to analyze the influencing factors of adverse pregnancy outcomes in GDM patients.Results:Compared with the control group,the serum levels of CTRP3 and PPARγin GDM group greatly decreased(P<0.01),the total incidence of adverse pregnancy outcomes greatly increased(P<0.01).Compared with the good pregnancy outcome group,the levels of FPG and HbA1c in the adverse pregnancy outcome group increased greatly,and the levels of serum CTRP3 and PPARγdecreased greatly(P<0.01).The serum levels of CTRP3 and PPARγin GDM patients with adverse pregnancy outcomes were negatively correlated with FPG and HbA1c(P<0.05).The AUC of serum CTRP3,PPARγand combination of both for predicting adverse pregnancy outcomes in GDM patients were 0.747,0.844 and 0.901,respectively.The CTRP3 and PPARγwere the protective factors for adverse pregnancy outcome in GDM patients(P<0.01).Conclusions:The serum levels of CTRP3 and PPARγin GDM patients are related to the adverse pregnancy outcome,and both of them have certain value in predicting the adver

关 键 词：妊娠期糖尿病 C1q/TNF相关蛋白3 过氧化物酶体增殖物激活受体Γ 妊娠结局 

分 类 号：R714.256[医药卫生—妇产科学]