冠心病病人血清sRANKL、suPAR含量与心电图QRS波时限相关性分析  

Correlation between serum content of sRANKL,suPAR and QRS wave time limit of electrocardiogram in patients with coronary heart disease

作　　者：谢巍 赖祯平 李林[1] XIE Wei;LAI Zhenping;LI Lin(Department of Cardiology,Bazhong Central Hospital,Bazhong Sichuan 636000,China)

机构地区：[1]四川省巴中市中心医院心血管内科,636000

出　　处：《蚌埠医科大学学报》2025年第3期355-358,共4页Journal of Bengbu Medical University

基　　金：四川省卫生健康委员会科研课题(20PJ310)。

摘　　要：目的:探讨冠心病病人血清可溶性核因子-κB受体活化因子配体(sRANKL)、可溶性尿激酶型纤溶酶原激活物受体(suPAR)含量与心电图QRS波时限相关性。方法:选择133例冠心病病人作为观察组,以同期体检健康者100名作为对照组。比较2组QRS波时限及血清sRANKL、suPAR含量,分析冠心病病人QRS波时限的影响因素及血清sRANKL、suPAR含量与QRS波时限相关性。结果:观察组血清sRANKL含量明显低于对照组(P<0.01),观察组QRS波时限和血清suPAR含量均明显高于对照组(P<0.01)。Pearson相关分析显示,冠心病病人血清sRANKL含量与QRS波时限呈负相关关系(r=-0.607,P<0.05),血清suPAR含量与QRS波时限呈正相关关系(r=0.588,P<0.05)。多元线性回归分析显示,sRANKL、suPAR是冠心病病人QRS波时限的影响因素(P<0.01)。结论:冠心病病人外周血中sRANKL呈低表达,suPAR呈高表达,两者均与心电图QRS波时限有相关关系,sRANKL、suPAR可能影响QRS波时限而共同参与冠心病发病过程。Objective:To investigate the correlation between serum content of soluble nuclear factor-κB receptor activator ligand(sRANKL),soluble urokinase type plasminogen activator receptor(suPAR)and QRS wave time limit of electrocardiogram in patients with coronary heart disease.Methods:One hundred and thirty-three patients with coronary heart disease were selected as the observation group,and 100 healthy examinees at the same period as the control group.The QRS wave time limit of electrocardiogram and serum content of sRANKL and suPAR were compared between the two groups.The influencing factors of QRS wave time limit,and the correlation between serum content of sRANKL,suPAR and QRS wave time limit of electrocardiogram in patients with coronary heart disease were analyzed.Results:The serum content of sRANKL in the observation group was significantly lower than that in the control group(P<0.01),and the QRS wave time limit and serum content of suPAR in the observation group were significantly higher than those in the control group(P<0.01).Pearson correlation analysis showed that the serum content of sRANKL was negatively correlated with QRS wave time limit(r=-0.607,P<0.05),and the serum content of suPAR was positively correlated with QRS wave time limit in patients with coronary heart disease(r=0.588,P<0.05).Multiple linear regression analysis showed that sRANKL and suPAR were the influencing factors of QRS wave time limit in patients with coronary heart disease(P<0.01).Conclusions:The expression of sRANKL is down-regulated,and the expression of suPAR is up-regulated in the peripheral blood of patients with coronary heart disease.Both of them are correlated with the QRS wave time limit of electrocardiogram.SRANKL and suPAR may affect the QRS time limit and participate in the pathogenesis and progression of coronary heart disease.

关 键 词：冠心病 可溶性核因子-κB受体活化因子配体 可溶性尿激酶型纤溶酶原激活物受体 心电图QRS波时限 

分 类 号：R541.4[医药卫生—心血管疾病]