从中医脾与肠道菌群对话阐述健脾益气法对亚甲状腺功能减退症防治的理论依据  

Theoretical basis of the Spleen-strengthening and Qi-tonifying Therapy for the prevention and treatment of subclinical hypothyroidism from the perspective of interaction between spleen and intestinal flora in TCM

作　　者：李晓钰 徐航 高天舒[2] 陈巍[1,3] Li Xiao-yu;XU Hang;GAO Tian-shu;CHEN Wei(Graduate School of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China;Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,China)

机构地区：[1]辽宁中医药大学研究生学院,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032 [3]辽宁中医药大学附属第二医院,辽宁沈阳110034

出　　处：《时珍国医国药》2025年第5期903-907,共5页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金青年基金(82004340);辽宁省博士启动金计划项目(2020-BS-045)。

摘　　要：“脾虚”是中医的一个重要病理变化,多项研究表明“脾虚”与肠道菌群失衡密切相关。甲状腺是从原始的肠道细胞发育而来的器官,肠道菌群的失调是亚临床甲减的一个关键病理环节,而甲状腺激素的水平或功能又会反过来影响肠道菌群的组成。近年来,有研究表明肠道菌群与甲状腺疾病关系密切,包括甲状腺功能减退症、桥本氏甲状腺炎、格雷夫斯病等,且在各甲状腺疾病的发生发展中起着重要作用,但对亚临床甲减与肠道菌群的研究却十分缺乏。文章从中医以脾论治的角度入手,论述健脾益气法通过调节肠道菌群失调对亚临床甲减的防治作用,进一步证实肠道菌群与亚临床甲减之间的关系,为防治亚临床甲减提供新的靶点与思路。In traditional Chinese medicine(TCM),spleen deficiency is a significant pathological concept,and numerous studies have demonstrated its tight association with intestinal flora imbalance.The thyroid gland originates from primitive intestinal cells,and dysbiosis of the intestinal flora is a key pathological factor in subclinical hypothyroidism(SCH).Conversely,thyroid hormone levels and function can also influence the composition of intestinal flora.Recent studies have highlighted a strong connection between intestinal flora and thyroid-related disorders,including hypothyroidism,Hashimoto's thyroiditis(HT),and Graves'disease(GD),with intestinal flora playing a vital role in their pathogenesis.However,specific studies on the relationship between SCH and intestinal flora remains limited.From the perspective of TCM's spleen-based treatment approach,this paper explores the role of the Spleen-strengthening and Qi-tonifying Therapy(SQT)in preventing and managing SCH by modulating intestinal flora imbalance.The discussion further verifies the correlation between intestinal flora and SCH,providing new insights and potential therapeutic targets for SCH prevention and treatment.

关 键 词：亚临床甲减 肠道菌群 健脾益气 脾-肠轴 甲状腺-肠轴 

分 类 号：R581[医药卫生—内分泌]