基于数据挖掘分析宋金元时期燕赵医家治疗月经病的用药规律  

Exploring the medication patterns in the treatment of menstrual disease by Yan-Zhao physicians during the Song,Jin and Yuan dynasties based on data mining

作　　者：王伟 武宏玉 王贺飞 刘旭 李定邦 马焕瑞 郝熠玮 车开萌 孙士江 WANG Wei;WU Hong-yu;WANG He-fei;LIU Xu;LI Ding-bang;MA Huan-rui;HAO Yi-wei;CHE Kai-meng;SUN Shi-jiang(School of Basic Medical Sciences,Hebei University of Chinese Medicine,Shijiazhuang 050091,China;First Affiliated Hospital of Hebei University of Chinese Medicine,Shijiazhuang 050000,China)

机构地区：[1]河北中医药大学基础医学院,河北石家庄050091 [2]河北中医药大学第一附属医院,河北石家庄050000

出　　处：《时珍国医国药》2025年第5期995-1000,共6页Lishizhen Medicine and Materia Medica Research

基　　金：河北省2024年政府资助临床医学优秀人才培养项目(ZF2024159);河北省中医药管理局科研计划项目(2025015)。

摘　　要：目的基于数据挖掘分析宋金元时期燕赵医家治疗月经病的用药规律,为临床月经病的治疗提供借鉴。方法通过查阅宋金元时期燕赵医家著作,筛选出其中治疗月经病的处方,运用Excel2021、古今医案云平台、SPSS Statistics 26.0、SPSS Modeler 18.0软件,对纳入的处方进行用药频次、四气、五味、归经、功效类别、关联规则、聚类分析、复杂网络分析。结果(1)共纳入处方106首,中药173味。中药使用频次≥10次作为高频中药,有当归(60次)、白芍(30次)、甘草(29次)等20味中药,高频药物以补虚药为主。(2)四气以温性、平性、微寒性为主,五味以辛味、苦味、甘味为主,药物多归为肝经、脾经、心经。(3)关联规则分析得到19组数据,聚类分析获得6类药物组成,复杂网络分析得到核心中药为熟地黄、当归、川芎、白芍、甘草、肉桂。结论宋金元时期燕赵医家在月经病的治疗用药上辛苦共用,补泻兼施;重视气血同调的同时,擅用舒肝之品,在继承传统经方的基础上创制新方。Objective To analyze the medication patterns of Yan-Zhao physicians in treating menstrual disease in the Song,Jin and Yuan dynasties based on data mining,providing insights for modern clinical practice.Methods Prescriptions for menstrual disease were extracted from Yan-Zhao physicians'medical works of the Song,Jin,and Yuan dynasties.Excel 2021,the Ancient and Modern Medical Case Cloud Platform,SPSS Statistics 26.0,and SPSS Modeler 18.0 were employed to analyze the frequency,four qi,five flavors,meridian tropism,efficacy categories,association rules,cluster analysis,and complex network analysis of the included prescriptions.Results(1)A total of 106 prescriptions and 173 Chinese medicinals were included.High-frequency Chinese medicinals(≥10 uses)comprised 20 ingredients,primarily deficiency tonifying herbs,including Angelicae Sinensis Radix(60 times),Paeoniae Radix Alba(30 times),and Glycyrrhizae Radix et Rhizoma(29 times).(2)Four qi were predominantly warm,mild,and slightly cold,and five flavors emphasized pungent,bitter,and sweet.Meridian tropism focused on the liver,spleen,and heart meridians.(3)Association patterns revealed 19 significant combinations,and cluster analysis identified 6 medicinal clusters.Complex network analysis highlighted core Chinese medicinals:Rehmanniae Radix Praeparata,Angelicae Sinensis Radix,Chuanxiong Rhizoma,Paeoniae Radix Alba,Glycyrrhizae Radix et Rhizoma,and Cinnamomi Cortex.Conclusion Yan-Zhao physicians treated menstrual disease with a balanced use of pungent and bitter herbs,combining purgation and tonification.They emphasized harmonizing qi and blood,prioritized liver-soothing medicinals,and developed innovative formulas while inheriting classical approaches.

关 键 词：月经病 燕赵医家 数据挖掘 用药规律 高频药物 

分 类 号：R271.11[医药卫生—中医妇科学]