脑心通胶囊联合单硝酸异山梨酯、尼可地尔治疗不稳定型心绞痛的效果分析  

Effect of Naoxintong Capsule Combined with Isosorbide Mononitrate and Nicodil in Treatment of Unstable Angina Pectoris

作　　者：许建超 许晶 陈爱竹 XU Jianchao;XU Jing;CHEN Aizhu(Department of Cardiology,Liaocheng People's Hospital,Liaocheng 252000,Shandong,China;The First Ward of Psychiatry,the Fourth People's Hospital of Liaocheng,Liaocheng 252000,Shandong,China;Department of General,Community Health Service Center,Gulou Street,Dongchangfu District,Liaocheng City,Shandong Province,Liaocheng 252000,Shandong,China)

机构地区：[1]聊城市人民医院心内科,山东聊城252000 [2]聊城市第四人民医院精神科一病房,山东聊城252000 [3]山东省聊城市东昌府区古楼街道社区卫生服务中心全科,山东聊城252000

出　　处：《世界复合医学(中英文)》2025年第3期24-27,共4页World Journal of Complex Medicine

摘　　要：目的 探讨对不稳定型心绞痛患者采用脑心通胶囊+单硝酸异山梨酯+尼可地尔治疗的临床效果。方法 回顾性选取2021年2月—2023年4月聊城市人民医院收治的80例不稳定型心绞痛患者的临床资料,依据不同的心绞痛治疗方法分为两组,对照组(40例)应用常规治疗+单硝酸异山梨酯+尼可地尔药物治疗;研究组(40例)在对照组基础上给予脑心通胶囊治疗;对比两组临床疗效、不良反应发生率、氧化应激指标与炎症因子水平。结果 治疗总有效率比较[97.50%(39/40)vs 82.50%(33/40)],研究组更高,差异有统计学意义(χ2=5.000,P<0.05)。不良反应发生率方面,两组比较,差异无统计学意义(P>0.05)。治疗后,研究组超氧化物歧化酶水平高于对照组,丙二醛、白细胞介素-6、中性粒细胞/淋巴细胞比值、同型半胱氨酸水平均低于对照组,差异均有统计学意义(P均<0.05)。结论 临床对不稳定型心绞痛患者联合应用脑心通胶囊+单硝酸异山梨酯+尼可地尔治疗,可明显提升治疗效果、改善氧化应激水平。Objective To explore the clinical effect of Naoxintong Capsule+isosorbide mononitrate+nicorandil in patients with unstable angina pectoris.Methods The clinical data of 80 patients with unstable angina pectoris admitted to Liaocheng People's Hospital from February 2021 to April 2023 were retrospectively selected.According to the different treatment methods of angina pectoris,they were divided into two groups.The control group(40 cases) was treated with conventional therapy+isosorbide mononitrate+nicorandil.The study group(40 cases) was treated with Naoxintong Capsule on the basis of the control group.The clinical efficacy,incidence of adverse reactions and oxidative stress and inflammatory factors levels were compared between the two groups.Results The total effective rate of treatment was compared [97.50%(39/40) vs 82.50%(33/40)],and the study group was higher,the difference was statistically significant(χ2=5.000,P<0.05).Incidence of adverse reactions,compared two groups,there was no statistically significant difference(P>0.05).After treatment,the level of superoxide dismutase in the study group was higher than that in the control group,and the levels of malondialdehyde,interleukin-6,neutrophil/lymphocyte ratio,homocysteine in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion The clinical treatment of Naoxintong Capsule+isosorbide mononitrate+nicorandil in patients with unstable angina pectoris can significantly improve the therapeutic effect and improve the level of oxidative stress.

关 键 词：脑心通胶囊 单硝酸异山梨酯 尼可地尔 不稳定型心绞痛 治疗效果 

分 类 号：R541.4[医药卫生—心血管疾病]