NLR-mediated antiviral immunity in plants  

作　　者：Min Zhu Mingfeng Feng Xiaorong Tao 

机构地区：[1]Department of Plant Pathology,Nanjing Agricultural University,Nanjing 210095,China

出　　处：《Journal of Integrative Plant Biology》2025年第3期786-800,共15页植物学报(英文版)

基　　金：supported by the Funds from the National Key Research and Development Program of China(Grant Nos.2022YFF1001500,2022YFD1401200);the National Natural Science Foundation of China(Grant Nos.32272488,31630062,32220103008,32430088,and 32102169);Jiangsu Provincial Key Research and Development Plan(Grant No.BE2022369);the Jiangsu Key Technology R&D Program and International Science and Technology Cooperation Project(Grant Nos.BZ2023030)。

摘　　要：Plant viruses cause substantial agricultural devastation and economic losses worldwide.Plant nucleotide-binding domain leucine-rich repeat receptors(NLRs)play a pivotal role in detecting viral infection and activating robust immune responses.Recent advances,including the elucidation of the interaction mechanisms between NLRs and pathogen effectors,the discovery of helper NLRs,and the resolution of the ZAR1 resistosome structure,have significantly deepened our understanding of NLR-mediated immune responses,marking a new era in NLR research.In this scenario,significant progress has been made in the study of NLRmediated antiviral immunity.This review comprehensively summarizes the progress made in plant antiviral NLR research over the past decades,with a focus on NLR recognition of viral pathogen effectors,NLR activation and regulation,downstream immune signaling,and the engineering of NLRs.

关 键 词：downstream immune signaling NLR recognition nucleotide-binding domain leucine-rich repeat receptors(NLRs) plant virus viral effectors 

分 类 号：S432.1[农业科学—植物病理学]