右美托咪定对老年患者预防术后躁动发生的影响  

Effect of Dexmedetomidine on Prevention of Postoperative Agitation in Elderly Patients

作　　者：吴旭[1] 王雷[2] 周蕾[1] 李金燕[1] 汤新[1] WU Xu;WANG Lei;ZHOU Lei;LI Jin-Yan;TANG Xin(Department of Anesthesiology,Zhongshan Hospital Affiliated to Dalian University,Dalian 11600l,Liaoning,China;Department of Orthopedics,967 Hospital,Joint Logistic Support Force,Chinese People's Liberation Army,Dalian 116000,China)

机构地区：[1]大连大学附属中山医院麻醉科,辽宁大连116001 [2]中国人民解放军联勤保障部队第九六七医院骨科,辽宁大连116000

出　　处：《中国药物经济学》2025年第2期82-84,92,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨右美托咪定对老年患者预防术后躁动发生的影响。方法选取2022年1月至2023年12月大连大学附属中山医院收治的老年骨折患者60例,随机分为试验组与对照组,各30例。对照组接受常规全身麻醉手术治疗,试验组在对照组基础上联合应用右美托咪定干预。比较两组患者术前、术后2 h心率(HR)、平均动脉压(MAP)、血氧饱和度(SpO_(2))及术后恢复与苏醒期情况、躁动评分、术后疼痛评分、苏醒期不良反应发生率、麻醉满意度。结果术前两组生命体征指标比较差异无统计学意义(P>0.05);术后2 h,试验组HR、MAP、SpO_(2)均高于对照组(P<0.05);试验组麻醉苏醒时间短于对照组(P<0.05),瑞芬太尼用量少于对照组(P<0.05);试验组躁动评分低于对照组(P<0.05),术后视觉模拟评分法(VAS)评分低于对照组(P<0.05),苏醒期不良反应发生率低于对照组(P<0.05);试验组麻醉满意度高于对照组(P<0.05)。结论对老年骨折患者实施右美托咪定麻醉,可显著改善手术期间生命体征变化,加速术后恢复与苏醒,缓解疼痛,降低术后躁动发生率,提升麻醉满意度。Objective To exolore the effect of dexmedetomidine on prevention of postoperative agitation in elderly patients.Methods Sixty elderly patients with fracture admitted to Zhongshan Hospital Affiliated to Dalian University from January 2022 to December 2023 were randomly divided into experimental group and control group,with 30 cases in each group.The control group received general anesthesia surgery,and the experimental group received dexmedetomidine combined intervention based on the control group.Heart rate(HR),mean arterial pressure(MAP),blood oxygen saturation(SpO_(2))before and 2 h after surgery,postoperative recovery and recovery,agitation score,postoperative pain score,incidence of adverse reactions during recovery and satisfaction with anesthesia were compared between the two groups.Results There was no significant difference in vital signs between the two groups before surgery(P>0.05).2 h after operation,HR,MAP and SpO_(2)in experimental group were higher than those in control group(P<0.05).The anesthesia recovery time of experimental group was shorter than that of control group(P<0.05),and the dosage of remifentanil was shorter than that of control group(P<0.05).The score of agitation in experimental group was lower than that in control group(P<0.05),the score of visual analogue scale(VAS)after surgery was lower than that in control group(P<0.05),and the incidence of adverse reactions during recovery was lower than that in control group(P<0.05).The satisfaction of anesthesia in experimental group was higher than that in control group(P<0.05).Conclusion Dexmedetomidine anesthesia in elderly patients with fracture can significantly improve the changes of patients'vital signs during surgery,accelerate postoperative recovery and recovery,relieve pain,reduce the incidence of postoperative agitation,and improve anesthesia satisfaction.

关 键 词：右美托咪定 老年患者 骨折 术后躁动 

分 类 号：R683.4[医药卫生—骨科学] R971[医药卫生—外科学]