淫羊藿苷抗骨质疏松症作用及机制研究进展  

Research Progress of Icariin in The Treatment of Osteoporosis

作　　者：包卓玛 江露 李玮怡 张宗星 刘道忠 袁林 BAO Zhuo-Ma;JIANG Lu;LI Wei-Yi;ZHANG Zong-Xing;LIU Dao-Zhong;YUAN Lin(Hubei Key Laboratory of Incidence and Intervention of Rheumatic Diseases,Hubei University for Nationalities,Enshi 445000,China;College of Medicine,Hubei Minzu University,Enshi 445000,China;Hubei Clinical Research Center of Nephrology,Enshi 445000,China;Department of Traditional Chinese Medicine Rehabilitation,Lichuan Hongxin Harmony Hospital,Enshi 445000,China)

机构地区：[1]湖北民族大学风湿性疾病发生与干预湖北省重点实验室,湖北恩施445000 [2]湖北民族大学医学部,湖北恩施445000 [3]湖北省肾脏病临床医学研究中心,湖北恩施445000 [4]利川宏信和谐医院中医康复科,湖北恩施445000

出　　处：《中国药物经济学》2025年第2期111-115,共5页China Journal of Pharmaceutical Economics

基　　金：恩施土家族苗族自治州科技局指导计划项目(恩施科业[2019]15号)。

摘　　要：骨质疏松症(OP)是由于多种原因导致的骨密度和骨质量下降,骨微结构破坏,造成骨脆性增加,从而容易发生骨折的全身性骨病。中药治疗OP具有高疗效、多靶点、经济实惠等优势。淫羊藿苷(ICA)作为中药淫羊藿的主要有效成分之一,其具有促进骨形成和抑制骨吸收的双重活性,近年来其已成为中药治疗OP的研究热点。现将通过分析国内外近年来的研究成果,从ICA作用于细胞和动物层面的研究成果,以及提高药物利用度等方面的研究现状做以下综述,为临床运用ICA治疗OP提供参考。Osteoporosis(OP)is a systemic bone disease that is prone to fractures due to a decrease in bone density and bone quality due to a variety of reasons,destruction of bone microstructure,and increased bone fragility.Traditional Chinese medicine in the treatment of OP has the advantages of high efficacy,multi-target,and economic benefits.As one of the main active ingredients of traditional Chinese medicine Epimedium,icariin(ICA)has the dual activities of promoting bone formation and inhibiting bone resorption,and has become a research hotspot in the treatment of OP with traditional Chinese medicine.By analyzing the research results at home and abroad in recent years,the following review will be made from the research results of ICA on the cell and animal level,as well as the research status of improving drug availability,so as to provide references for the clinical application of ICA in the treatment of OP.

关 键 词：淫羊藿苷 骨质疏松症 破骨细胞 成骨细胞 

分 类 号：R681.1[医药卫生—骨科学] R285.5[医药卫生—外科学]