地胆草中1个新的三萜  

A new triterpenoid from Elephantopus scaber

作　　者：丁祖霄 谢红茜 陈林 郝俊杰 罗艳秋 江志勇 徐士奎 DING Zu-xiao;XIE Hong-xi;CHEN Lin;HAO Jun-jie;LUO Yan-qiu;JIANG Zhi-yong;XU Shi-kui(Yunnan Key Laboratory of Pharmacology for Natural Products,School of Pharmacy,Kunming Medical University,Kunming 650500,China;Key Laboratory of Dai and Yi Medicine in Yunnan Province,Key Laboratory of Modern Research on Ethnic Medicine in Yunnan Provincial Universities,School of Ethnomedicine,Yunnan University of Chinese Medicine,Kunming 650500,China;College of Traditional Chinese Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China;MIIT Public Service Platform for Industrial Technology Foundation,Yunnan Institute for Food and Drug Control,Kunming 650106,China)

机构地区：[1]昆明医科大学药学院云南省天然药物药理重点实验室,云南昆明650500 [2]云南中医药大学民族医药学院云南省傣医药与彝医药重点实验室云南省高校民族药现代研究重点实验室,云南昆明650500 [3]云南中医药大学中药学院,云南昆明650500 [4]云南省食品药品监督检验研究院工业和信息化部产业技术基础公共服务平台,云南昆明650106

出　　处：《中国中药杂志》2025年第5期1224-1230,共7页China Journal of Chinese Materia Medica

基　　金：云南省市场监管科学研究计划项目(2022YSJK08);兴滇英才支持计划项目;云南省科技计划项目重大科技专项生物医药专项(202402AA310030);云南省中医药联合专项重点项目(202101AZ070001-164);云南省教育厅高原特色民族药用植物研究科技创新团队项目;国家中医药管理局高水平中医药重点学科建设项目(Zyyzdxk-2023192)。

摘　　要：采用硅胶柱色谱、C18柱色谱、MCI柱色谱以及半制备型高效液相色谱等色谱手段对地胆草90%乙醇提取物的石油醚萃取部分进行化学成分研究,从中分离鉴定了10个化合物。通过1D NMR、2D NMR、MS、IR等波谱数据及理化性质分别鉴定为3β-hydroxy-6β,7β-epoxytaraxeran-14-ene(1)、3β-hydroxyolean-12-en-28-oic acid(2)、D-friedoolean-14-ene-3β,7α-diol(3)、3β-hydroxy-11α-methoxyolean-12-ene(4)、3β-hydroxyolean-11,13(18)-diene(5)、11α-hydroxy-β-amyrin(6)、betulinic acid(7)、3β-hydroxy-30-norlupan-20-one(8)、6-acetonylchelerythrine(9)、4′,5′-dehydrodiodictyonema A(10)。其中化合物1为1个新的三萜。除化合物2、7外,其余化合物均为首次从该植物中分离得到。The chemical constituents of the petroleum ether extract derived from the 90%ethanol extract of Elephantopus scaber were investigated.By silica gel column chromatography,C18,MCI column chromatography and semi-preparative high performance liquid chromatography,ten compounds were isolated.Their structures were identified as 3β-hydroxy-6β,7β-epoxytaraxeran-14-ene(1),3β-hydroxyolean-12-en-28-oic acid(2),D-friedoolean-14-ene-3β,7α-diol(3),3β-hydroxy-11α-methoxyolean-12-ene(4),3β-hydroxyolean-11,13(18)-diene(5),11α-hydroxy-β-amyrin(6),betulinic acid(7),3β-hydroxy-30-norlupan-20-one(8),6-acetonylchelerythrine(9),and 4′,5′-dehydrodiodictyonema A(10)by analysis of the 1D NMR,2D NMR,MS,and IR spectral data.Among them,compound 1 was a new triterpene and other compounds except compounds 2 and 7 were isolated from this plant for the first time.

关 键 词：地胆草 三萜 3β-hydroxy-6β 7β-epoxytaraxeran-14-ene 

分 类 号：R284.1[医药卫生—中药学]