针灸治疗功能性胃肠病的机制研究进展:述评与展望  

Mechanism research progress on acupuncture-moxibustion therapy for functional gastrointestinal disorders:review and prospects

作　　者：方誉澄 朱敬伟 王子叶 李奎武 丁雪纯 王宁 储浩然 FANG Yucheng;ZHU Jingwei;WANG Ziye;LI Kuiwu;DING Xuechun;WANG Ning;CHU Haoran(Anhui University of CM,Hefei 230031,China;Second Clinical Medical School of Anhui University of CM,Hefei 230061;Shenzhen Luohuo Hospital of TCM;Clinical Institute of Acupuncture and Moxibustion,Anhui Academy of TCM,Hefei 230061;Anhui Clinical Medical Research Center of Acupuncture and Moxibustion,Hefei230061;Institute of Xin'an Medicine and Chinese Medicine Modernization,Anhui University of CM,Hefei 230012)

机构地区：[1]安徽中医药大学,合肥230031 [2]安徽中医药大学第二临床医学院,合肥230061 [3]深圳市罗湖区中医院 [4]安徽省中医药科学院针灸临床研究所,合肥230061 [5]安徽省针灸临床医学研究中心,合肥230061 [6]安徽中医药大学新安医学与中医药现代化研究所,合肥230012

出　　处：《中国针灸》2025年第4期551-558,共8页Chinese Acupuncture & Moxibustion

基　　金：国家自然科学基金面上项目:81774399;储浩然全国名老中医药专家传承工作室项目:国中医药人教函[2022]75号;安徽省针灸临床医学研究中心开放基金项目:2021zjzx01;安徽省重点研究与开发计划项目:202204295107020046;安徽省中医药科技攻关专项项目:202303a07020006;合肥综合性国家科学中心大健康研究院新安医学与中医药现代研究所“揭榜挂帅”项目:2023CXMMTCMO17。

摘　　要：针灸被认为可以改善功能性胃肠病(FGIDs)症状,然而其具体作用机制至今仍不明确。本文梳理近5年关于针灸治疗FGIDs的文献,发现针灸可通过调节胃肠动力、调节内脏高敏感、改善胃-十二指肠黏膜屏障功能受损及炎性反应、调节肠道菌群失衡、调控脑-肠轴来改善FGIDs相关症状。目前,针灸治疗FGIDs的分子机制仍不清晰,其具体的疾病靶点不甚明确,对各分子间相互作用机制的阐述欠完备,未来仍需要利用更先进的研究技术及手段进行深入、全面的探究,以阐明针灸治疗FGIDs的起效机制。Acupuncture-moxibustion therapy has been known to ameliorate the symptoms of functional gastrointestinal disorders(FGIDs),although its mechanism remains unclear.The paper reviews the articles on acupuncture-moxibustion therapy for FCIDs in recent 5 years,and it is revealed that acupuncture-moxibustion therapy can alleviate FGIDs symptoms through regulating gastrointestinal motility,modulating visceral hypersensitivity,improving the impaired gastric-duodenal mucosal barrier and inflammation,balancing intestinal microbiota,and adjusting the gut-brain axis.Currently,the molecular mechanism of acupuncture-moxibustion therapy remains unknown for FGIDs,the specific disease target is not identified,and the interaction among various molecules is not elucidated adequately.The researches in the future should employ advanced technologies and methodologies to comprehensively and deeply explore and clarify the mechanism of acupuncturemoxibustion therapyforFGIDs.

关 键 词：功能性胃肠病 功能性消化不良 肠易激综合征 针灸 机制 述评 

分 类 号：R245[医药卫生—针灸推拿学]