HIV感染者开展结核病预防性治疗的研究进展  

Research progress on preventive treatment of tuberculosis in HIV-infected persons

作　　者：杨芳 黄琼 张云桂 YANG Fang;HUANG Qiong;ZHANG Yungui(School of Public Health,Dali University,Dali,Yunnan 671000,China;Yunnan Infectious Disease Hospital,Kunming,Yunnan 650301,China)

机构地区：[1]大理大学公共卫生学院,云南大理671000 [2]云南省传染病医院,云南昆明650301

出　　处：《实用预防医学》2025年第2期253-256,F0003,共5页Practical Preventive Medicine

基　　金：云南省张文宏专家工作站(202105AF150027);云南省感染性疾病(艾滋病)临床研究中心子课题——HIV感染者结核病预防性治疗队列研究(202102AA310005-014)。

摘　　要：人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者为结核病(tuberculosis,TB)发病的高危人群,当HIV感染者发生活动性TB时会导致患者生命质量下降,甚至危及生命。既往研究证明在HIV感染者中开展TB预防性治疗可以显著降低TB发病率,且该项预防措施是安全、可行的,但目前在我国普及该项预防措施依然面临许多困难。本研究针对HIV感染者/AIDS患者结核感染现状、TB预防性治疗进展进行综述,探讨在我国HIV感染者/AIDS患者中开展TB预防性治疗的难点、今后的工作思路以及还需加强的重点内容,为推广HIV感染者/AIDS患者开展TB预防性治疗工作提供借鉴。Persons infected with human immunodeficiency virus(HIV)are the high-risk group for tuberculosis(TB).When HIV-infected persons have active TB,their quality of life will decline or even endanger their lives.Previous studies have proved that preventive treatment of TB in HIV-infected persons can significantly reduce the incidence rate of TB,and the preventive measure is safe and feasible.However,there are still many difficulties in popularizing the preventive measure in China at present.This study reviews the current status of TB infection in HIV-infected persons/AIDS patients and the progress of preventive treatment of TB,and discusses the difficulties,future work ideas and the key content to be strengthened in carrying out preventive treatment of TB among HIV-infected persons/AIDS patients in China so as to provide references for promoting HIV-infected persons/AIDS patients to receive preventive treatment of TB.

关 键 词：人类免疫缺陷病毒 获得性免疫缺陷综合征 结核病 结核分枝杆菌 潜伏感染 预防性治疗 

分 类 号：R512.91[医药卫生—内科学] R52[医药卫生—临床医学]