疲劳模型的建立及中药抗疲劳作用研究进展  

Establishment of fatigue model and research progress of anti-fatigue effect of traditional Chinese medicine

作　　者：黄保年 车环宇 刘雪坤[1,2] 郭鑫 HUANG Baonian;CHE Huaqnyu;LIU Xuekun;GUO Xin(School of Pharmacy,Yanbian University,Yanbian 133000,China;School of Medicine,Tonghua Normal University,Tonghua 134000,China)

机构地区：[1]延边大学药学院,吉林延边133000 [2]通化师范学院医药学院,吉林通化134000

出　　处：《中草药》2025年第5期1805-1816,共12页Chinese Traditional and Herbal Drugs

基　　金：吉林省中医药管理局项目(2024200)。

摘　　要：疲劳是一个复杂的生理现象,严重影响着人们的生活质量。近年来,关于疲劳的研究在不断增加,研究表明疲劳成因呈现多样化,包括过度劳累、睡眠不足、营养不良、慢性疾病及心理压力等。为缓解相关人群疲劳症状、提高工作效率和生活质量,寻找安全有效的治疗方法迫在眉睫。目前,大多数相关实验研究是在啮齿类动物模型上进行。基于对常见疲劳动物模型造模方法的深入研究与系统总结,整理并分析了中药治疗疲劳的研究现状,为未来抗疲劳研究提供理论依据和参考。Fatigue is a complex physiological phenomenon that significantly impacts quality of life.In recent years,research on fatigue has been increasing,with studies demonstrating that its etiology manifests diversely,including factors such as overexertion,sleep deprivation,nutritional deficiencies,chronic diseases,and psychological stress.To alleviate fatigue symptoms in affected populations and enhance work efficiency and life quality,there is an urgent need to identify safe and effective therapeutic interventions.Currently,most experimental studies in this field are conducted using rodent models.Through in-depth investigation and systematic summarization of established modeling methods in common animal fatigue models,this paper collates and analyzes the current research status of traditional Chinese medicine in treating fatigue,aiming to provide theoretical foundations and references for future antifatigue research.

关 键 词：中药 抗疲劳 动物模型 氧化应激 能量代谢 代谢产物 免疫信号 肠道菌群 

分 类 号：R285[医药卫生—中药学]