白芍活性成分、药理作用及成分变化的影响因素研究进展  

Research progress on active ingredients,pharmacological effects and influencing factors of component changes of Paeoniae Radix Alba

作　　者：王秋艳 王世新 隋方宇[1] 张淼[1] 关子赫 胥风华[2] 旺建伟[1] WANG Qiuyan;WANG Shixin;SUI Fangyu;ZHANG Miao;GUAN Zihe;XU Fenghua;WANG Jianwei(Heilongjiang University of Chinese Medicine,Harbin 150040,China;First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中草药》2025年第5期1817-1829,共13页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金面上项目(81573870);国家中医药管理局第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]239号);国家中医药管理局第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]1号)。

摘　　要：白芍Paeoniae Radix Alba为临床常用的中药,主治胸腹胁肋疼痛、泻痢腹痛、自汗盗汗、阴虚发热、月经不调、崩漏等。其功效与其活性成分密切相关,现代药理研究表明,白芍有保肝、抗肝纤维化、镇痛、抗抑郁、降血糖、心血管保护、抗氧化、调节免疫及抗肿瘤等作用。目前研究发现,产地、种质、栽培措施、采收加工、炮制方法等因素均会导致活性成分含量差异,并影响其药理作用。通过查阅历代本草、医药典籍及国内外相关文献,从白芍的活性成分、药理作用及影响活性成分表达的因素进行论述,为白芍今后研究、临床应用及相关药品的开发提供理论参考。Baishao(Paeoniae Radix Alba)is a commonly used traditional Chinese medicine in clinical practice.It mainly treats chest,abdominal pain,diarrhea and abdominal pain,spontaneous sweating,night sweats,yin deficiency fever,irregular menstruation,metrorrhagia,etc.Its efficacy is closely related to its active ingredients.Modern pharmacological studies have shown that Paeoniae Radix Alba has liver protection,anti-liver fibrosis,analgesia,antidepressant,blood sugar lowering,cardiovascular protection,antioxidant,immune regulation and anti-tumor effects.Current research has found that factors such as origin,germplasm,cultivation measures,harvesting processing,processing methods,storage,compatibility and decocting methods will all lead to differences in the content of active ingredients and affect the pharmacological effects.The active ingredients,pharmacological effects and the influence of various factors on its active ingredients of Paeoniae Radix Alba by reviewing the herbal medicines,medical classics and relevant literature at home and abroad,to provide theoretical reference for future research,clinical application and development of related pharmaceuticals Paeoniae Radix Alba.

关 键 词：白芍 白芍总苷 白芍多糖 保肝 抗炎 镇痛 炮制 产地 采收加工 配伍 

分 类 号：R285[医药卫生—中药学]