姜黄素对糖尿病肾病的治疗作用及相关机制研究进展  

Research progress on therapeutic effects and related mechanisms of curcumin on diabetic nephropathy

作　　者：董朋涛 王耀献[2,4] 李晓羽 高亚斌 冯雪 赵自然 张青 王峥[1,4] DONG Pengtao;WANG Yaoxian;LI Xiaoyu;GAO Yabin;FENG Xue;ZHAO Ziran;ZHANG Qing;WANG Zheng(Department of Nephrology,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China;School of Public Health,Zhengzhou University,Zhengzhou 450001,China;Collaborative Innovation Center of TCM and Western Medicine for Prevention and Treatment of Major Diseases in Henan Province,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院肾病科,河南郑州450000 [2]河南中医药大学,河南郑州450046 [3]郑州大学公共卫生学院,河南郑州450001 [4]中西医防治重大疾病河南省协同创新中心,河南郑州450000

出　　处：《中草药》2025年第5期1830-1839,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82405343);河南省中医药拔尖人才培养项目(2022ZYBJ08);河南省科技攻关项目(232102310458);河南省中医药科学研究专项(2019JDZX2116);河南省高等学校重点科研项目(25A360004)。

摘　　要：糖尿病肾病(diabetic nephropathy,DN)是糖尿病患者常见的微血管并发症之一,已成为导致终末期肾病的主要原因。该病起病隐匿,在临床治疗中往往错过最佳干预时机,严重影响患者的生活质量和生命安全。姜黄素是一种从姜黄根茎中提取的多酚类化合物,具有广泛的药理作用。近年来,随着对姜黄素研究的不断深入,其在DN治疗中的应用受到广泛关注。通过分析姜黄素治疗DN的临床前研究和临床研究,发现其能够通过改善糖脂代谢紊乱、抑制炎症反应和氧化应激、减轻肾纤维化与细胞凋亡、调节肠道菌群失衡及维持自噬平衡等多种机制,对DN发挥保护作用。为姜黄素治疗DN的基础研究、药物开发与临床应用提供重要参考。Diabetic nephropathy(DN)is one of the common microvascular complications in patients with diabetes mellitus,and has become a major cause of end-stage renal disease.The disease has an insidious onset and often misses the best time for intervention in clinical treatment,which seriously affects the quality of life and life safety of patients.Curcumin is a polyphenolic compound extracted from the rhizome of Jianghuang(Curcumae Longae Rhizoma),which has a wide range of pharmacological effects.In recent years,with the continuous deepening of the research on curcumin,its application in treatment of DN has received widespread attention.By analyzing the preclinical and clinical studies of curcumin in treatment of DN,it was found that it can exert a protective effect on DN through a variety of mechanisms,such as improving the disorders of glucose and lipid metabolism,inhibiting inflammatory response and oxidative stress,attenuating renal fibrosis and apoptosis,regulating the imbalance of intestinal flora,and maintaining the balance of autophagy.To provide an important reference for the basic research,drug development and clinical application of curcumin in treatment of DN.

关 键 词：糖尿病肾病 姜黄素 姜黄素类似物 糖脂代谢紊乱 氧化应激 肠道菌群 

分 类 号：R285[医药卫生—中药学]