逍遥散干预对女童特发性性早熟疗效及对雌激素受体1(ESR1)信号通路的影响  

Effect of Xiaoyao Powder on Idiopathic Precocious puberty in girls and its influence on estrogen receptor1(ESR1)signaling pathway

作　　者：屠倩倩 王静 孙建华[1] TU Qianqian;WANG Jing;SUN Jianhua(Department of Pediatrics,Huzhou Hospital of Traditional Chin Medicine,Huzhou,Zhejiang 313000,China)

机构地区：[1]湖州市中医院儿科,浙江湖州313000

出　　处：《中国病原生物学杂志》2025年第5期577-581,共5页Journal of Pathogen Biology

基　　金：湖州市科技局项目(No.2021GYB45)。

摘　　要：目的本研究旨在探讨在病原微生物感染背景下,传统中医药方剂逍遥散对女童特发性性早熟(Idiopathic Central Precocious Puberty,ICPP)的治疗效果及其对雌激素受体1(Estrogen Receptor 1,ESR1)信号通路的影响。方法通过随机对照试验设计,将80例病原微生物感染的ICPP患者随机分为治疗组和对照组,每组40例。治疗组在常规治疗基础上加用逍遥散,对照组仅接受常规治疗。结果治疗组总有效率为85.00%,显著高于对照组的67.50%。治疗组ESR1蛋白表达水平治疗后显著降低,ESR1信号通路相关因子表达水平也呈现下降趋势(均P<0.05)。此外,治疗组不良反应发生率低于对照组,显示出逍遥散辅助治疗具有较高的安全性。在激素水平方面,治疗组治疗后雌二醇(E2)、卵泡刺激素(FSH)和促黄体生成素(LH)水平显著降低(均P<0.05)。乳腺发育方面,治疗组在治疗前后的Tanner分级平均值有显著提高(P<0.05)。骨龄增长方面,治疗组的治疗后平均骨龄和骨龄增长速度均高于对照组(均P<0.05)。结论逍遥散能够通过调节ESR1信号通路,降低激素水平,促进乳腺发育,提高ICPP患者的临床疗效,为病原微生物感染背景下的ICPP治疗提供了新的思路和方法。Objective This study aims to investigate the therapeutic effect of traditional Chinese medicine prescription Xiaoyao Powder on girls'Idiopathic Central Precious Puberty(ICPP)and its influence on the estrogen receptor 1(ESR1)signaling pathway in the context of pathogenic microbial infection.Methods Through a randomized controlled trial design,80 patients with ICPP infected by pathogenic microorganisms were randomly divided into a treatment group and a control group,with 40 patients in each group.The treatment group received Xiaoyao Powder on the basis of conventional treatment,and the control group only received conventional treatment.Results The total effective rate in the treatment group was 85.00%,which was significantly higher than 67.50% in the control group.The expression level of ESR1 protein in the treatment group decreased significantly after treatment,and the expression level of factors related to ESR1 signaling pathway also showed a downward trend(both P<0.05).In addition,the incidence of adverse reactions in the treatment group was lower than that in the control group,indicating that Xiaoyao Powder has high safety as an adjuvant treatment.In terms of hormone levels,the levels of estradiol(E2),follicle stimulating hormone(FSH)and luteinizing hormone(LH)were significantly reduced in the treatment group after treatment(P<0.05 for all).In terms of breast development,the average value of Tanner classification in the treatment group before and after treatment was significantly improved(P<0.05).In terms of bone age growth,the average bone age and bone age growth rate after treatment in the treatment group were higher than those in the control group(both P<0.05).Conclusion Xiaoyao Powder can regulate the ESR1 signal pathway,reduce hormone levels,promote breast development,and improve the clinical efficacy of ICPP patients,providing new ideas and methods for the treatment of ICPP in the context of pathogenic microbial infections.

关 键 词：逍遥散 特发性性早熟 ESR1信号通路 病原微生物感染 激素 

分 类 号：R272[医药卫生—中医儿科学] R725.8[医药卫生—中医学]