85例难治性肺炎支原体肺炎患者医院感染的病原菌分布及危险因素调查  

Analysis of distribution of pathogenic bacteria and risk factors of nosocomial infection in 85patients with refractory Mycoplasma pneumoniae pneumonia

作　　者：许丽君 王雅鑫 王超[1] 朱亚宁 XU Lijun;WANG Yaxin;WANG Chao;ZHU Yaning(Department of Intensive Care Medicine,Wuhu Hospital Affiliated to East China Normal University(the Second People's Hospital of Wuhu),Wuhu 241000,Anhui,China;Blood Purification Center,Wuhu Hospital Affiliated to East China Normal University(the Second People's Hospital of Wuhu))

机构地区：[1]华东师范大学附属芜湖医院(芜湖市第二人民医院)重症医学科,安徽芜湖241000 [2]华东师范大学附属芜湖医院(芜湖市第二人民医院)血液净化中心,安徽芜湖241000

出　　处：《中国病原生物学杂志》2025年第5期610-613,共4页Journal of Pathogen Biology

基　　金：2023年安徽省临床医学研究转化专项项目(No.202304295107020001)。

摘　　要：目的观察85例难治性肺炎支原体肺炎(RMPP)患者医院感染的病原菌分布,并分析其危险因素。方法选择2023年10月-2024年2月本院收治的85例RMPP患者,根据其是否发生医院感染分组,分析发生医院感染的RMPP患者的病原菌分布情况,同时分析RMPP患者医院感染的独立危险因素。结果85例RMPP患者共35例(占41.18%)发生医院感染。35例发生医院感染的RMPP患者中,21例(占60.00%)细菌感染、8例(占22.86%)病毒感染、6例(占17.14%)肺炎衣原体感染。Logistic回归分析结果显示:年龄“≥60岁”(OR=2.535,P=0.001)、有侵入性操作(OR=4.684,P=0.021)、白细胞计数异常(OR=5.358,P=0.004)、C反应蛋白≥40 mg/L(OR=2.821,P=0.001)、住院时间“≥2周”(OR=3.935,P=0.001)、预防性使用抗菌药物(OR=1.483,P=0.004)是RMPP患者医院感染的独立危险因素。结论RMPP患者医院感染的病原菌主要为细菌感染,导致RMPP患者医院感染的独立危险因素包括年龄“≥60岁”、有侵入性操作、白细胞计数异常、C反应蛋白≥40 mg/L、住院时间“≥2周”、预防性使用抗菌药物,据此采取针对性防范措施,或利于减少RMPP患者医院感染的发生。Objective To observe the distribution of pathogenic bacteria in 85 refractory Mycoplasma pneumoniae pneumonia(RMPP)patients with nosocomial infection and analyze the risk factors.Methods Eighty-five patients with RMPP admitted to our hospital from October 2023 to February 2024 were selected.Based on whether they had nosocomial infection,the distribution of pathogens in RMPP patients with nosocomial infection was analyzed,and independent risk factors for nosocomial infection in RMPP patients were also analyzed.Results A total of 35 out of 85 patients with RMPP(41.18%)developed nosocomial infection.Among 35 patients with RMPP who developed nosocomial infection,21 cases(60.00%)were bacterial infections,8 cases(22.86%)were viral infections,and 6 cases(17.14%)were Chlamydia pneumoniae infections.The results of Logistic regression analysis showed that age≥60 years old(OR=2.535,P=0.001),invasive procedures(OR=4.684,P=0.021),abnormal white blood cell count(OR=5.358,P=0.004),C-reactive protein≥40 mg/L(OR=2.821,P=0.001),length of hospital stay≥2 weeks(OR=3.935,P=0.001),and prophylactic use of antibiotics(OR=1.483,P=0.004)were independent risk factors for nosocomial infection in patients with RMPP.Conclusion The main pathogen causing nosocomial infection in patients with RMPP is bacterial infection.Independent risk factors for nosocomial infection in RMPP include age≥60 years old,invasive procedures,abnormal white blood cell count,C-reactive protein≥40 mg/L,hospital stay≥2 weeks,and prophylactic use of antibiotics.Accordingly,taking targeted preventive measures may help to reduce the occurrence of nosocomial infections in patients with RMPP.

关 键 词：难治性肺炎支原体肺炎 病原菌 危险因素 

分 类 号：R563.1[医药卫生—呼吸系统]