代谢性疾病的表观转录组学研究  

Epigenomic study of metabolic diseases

作　　者：曹姝贤 刘冬 逯素梅[2] CAO Shuxian;LIU Dong;LU Sumei(School of Medical Laboratory Science,Shandong Second Medical University,Weifang 261053,Shandong,China;Department of Clinical Laboratory,the First Affiliated Hospital of Shandong First Medical University(Qianfoshan Hospital of Shandong Province),Shandong Provincial Key Laboratory of Clinical Laboratory Diagnosis in Medicine and Health)

机构地区：[1]山东第二医科大学医学检验学院,山东潍坊261053 [2]山东省第一医科大学第一附属医院检验科(山东省千佛山医院),山东省医药卫生临床检验诊断重点实验室

出　　处：《中国病原生物学杂志》2025年第5期661-665,660,共6页Journal of Pathogen Biology

基　　金：山东省自然科学基金资助项目(No.ZR2023MH031)。

摘　　要：目前对RNA修饰的研究越来越热门,虽然在基因转录调控中起主要作用的是DNA和组蛋白的表观遗传修饰,但是转录后的RNA修饰,即表观转录组,通过调节RNA的稳定性、定位和解码效率,同样对基因表达产生重要影响。RNA修饰的遗传变异或转录组修饰因子(比如编码器、消码器、读码器)在环境因素干扰下与代谢性疾病(如肥胖、2型糖尿病)之间存在关联。表观转录组与表观遗传信号密切相关,这让我们对基因表达在健康以及疾病发生发展过程中呈现出的复杂性有了更为深入的理解。另外,亲代的表观转录组修饰也可能影响下一代的生物特征。本文探讨了表观转录组修饰与代谢性疾病的关系,以及它们与表观基因组的关联,同时也讨论了可能的治疗策略。Currently,research on RNA modifications is becoming increasingly popular.Although epigenetic modifications of DNA and histones play a major role in the regulation of gene transcription,post-transcriptional RNA modifications,namely the epitranscriptome,also have a significant impact on gene expression by regulating RNA stability,localization and decoding efficiency.Genetic variations in RNA modifications or transcriptome modification factors(such as writers,erasers,and readers)are associated with metabolic diseases(such as obesity and Type 2 diabetes)under the interference of environmental factors.The epitranscriptome is closely related to epigenetic signals,which enables us to gain a deeper understanding of the complexity of gene expression in both health and the occurrence and development of diseases.In addition,parental epitranscriptome modifications may also affect the biological characteristics of the next generation.This article explores the relationship between epitranscriptome modifications and metabolic diseases,as well as their association with the epigenome,and also discusses possible treatment strategies.

关 键 词：代谢性疾病 RNA修饰 MRNA TRNA 综述 

分 类 号：R589[医药卫生—内分泌]