肠道菌群在脊髓损伤后神经功能损害中的研究进展  

Research progress on gut microbiota in neurological dysfunction after spinal cord injury

作　　者：房星辰 王宇红 FANG Xingchen;WANG Yuhong(The Second Emergency Department,Shengjing Hospital Affiliate China Medical University,Shenyang 110000,China)

机构地区：[1]中国医科大学附属盛京医院第二急诊科,辽宁沈阳110000

出　　处：《中国病原生物学杂志》2025年第5期674-676,682,共4页Journal of Pathogen Biology

摘　　要：脊髓损伤为一种严重的身体损伤,可导致患者出现运动、感觉等脑功能损伤,从而使生存质量受到极大影响。近年来,研究发现,脊髓损伤的发生可破坏肠道稳态,致使肠道菌群结构变化及代谢物失调。上述改变可经由微生物-肠-脑轴和中枢神经产生联系,引起神经功能障碍。故本文对肠道菌群和脊髓损伤后神经功能损害的研究现况进行了综述,旨在详细了解两者间的关系。Spinal cord injury is a serious physical injury,it can cause brain function damage such as movement and sensation in patients,and greatly affects their quality of life.In recent years,studies have found that spinal cord injury can disrupt gut homeostasis,leading to changes in gut microbiota structure and metabolic imbalances.The above changes can be linked to the central nervous system through the microbiota-gut-brain axis,thereby causing neurological dysfunction.Therefore,this article reviews the current research status of gut microbiota and neurological dysfunction after spinal cord injury,aiming to gain a detailed understanding of the relationship between the two.

关 键 词：肠道菌群 脊髓损伤 神经功能损害 综述 

分 类 号：R651.2[医药卫生—外科学]