禽传染性支气管炎病毒免疫机制的研究进展  

Progress on immune mechanism of avian infectious bronchitis

作　　者：李阳[1] 樊爱丽 陈吉林 董丽娜 左宗辉 马淑慧 徐刚 LI Yang;FAN Aili;CHEN Jilin;DONG Lina;ZUO Zonghui;MA Shuhui;XU Gang(Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry,College of Animal Science and Veterinary Medicine,Tianjin Agricultural University,Tianjin 300392,China;Hengnuoyou(Tianjin)Biotechnology Co.,Ltd.,Tianjin 301600,China)

机构地区：[1]天津农学院、动物科学与动物医学学院、天津市农业动物繁育与健康养殖重点实验室,天津300392 [2]恒诺优(天津)生物技术有限公司,天津301600

出　　处：《中国兽医学报》2025年第3期619-626,共8页Chinese Journal of Veterinary Science

基　　金：天津市教委科研计划资助项目(2020KJ097)。

摘　　要：禽传染性支气管炎(infectious bronchitis,IB)是由禽传染性支气管炎病毒(infectious bronchitis virus,IBV)引起鸡的一种急性、高度接触性传染病,IBV变异程度高,现有的免疫手段常无法达到良好的效果,严重影响国内养禽业的发展。通过对IBV的非特异性免疫、黏膜免疫以及特异性免疫等3个方面现阶段免疫应答分子机制的综述,以期为IBV免疫机制的研究提供理论参考。Avian infectious bronchitis(IB),a rapidly spreading and acute disease in chickens,is caused by the infectious bronchitis virus(IBV).IB is characterized by its remarkable genetic variability.IBV has a high degree of mutation,and the existing means of immunization often fail to achieve good results,seriously affecting the development of the domestic poultry industry.This article offers a comprehensive review of the current understanding of the immune response to IBV,focusing on three key areas:non-specific immunity,mucosal immunity,and specific immunity.By dissecting these aspects,the aim is to provide a theoretical reference for the study of the immune mechanism of IBV.

关 键 词：禽传染性支气管炎病毒 免疫应答 分子机制 

分 类 号：S852.65[农业科学—基础兽医学]