中药衍生碳点的制备、表征方法及其药理作用研究进展  

Research progress in preparation,characterization methods,and pharmacological activities of carbon dots derived from traditional Chinese medicine

作　　者：张涛 施冲煜 王青平 刘俊超 刘建群 ZHANG Tao;SHI Chongyu;WANG Qinping;LIU Junchao;LIU Jianqun(Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室,江西南昌330004

出　　处：《中草药》2025年第6期2224-2237,共14页Chinese Traditional and Herbal Drugs

基　　金：江西省研究生创新专项项目(YC2024-B221);江西中医药大学校级科技创新团队发展计划(CXTD22007)。

摘　　要：碳点(carbon dots,CDs)是一种粒径小于10 nm的新型荧光纳米粒子,中药衍生碳点(carbon dots derived from traditional Chinese medicine,TCM-CDs)是以中药为前驱体制备而成的CDs。与传统CDs相比,TCM-CDs以天然中药为前驱体,资源丰富,符合绿色化学原则;中药中含有丰富的活性成分赋予了TCM-CDs独特的药理活性和生物相容性,有助于药物递送和靶向治疗,进而可能发挥更大的药用价值。TCM-CDs的制备过程成本低廉,适合大规模应用,进一步拓展了其在生物医学领域的潜在价值。由此,近年来TCM-CDs得到了广泛的关注和研究。通过详细介绍TCM-CDs的来源、制备方法及每种制备方法的优缺点,系统总结TCM-CDs的结构特征、性质与表征方法,全面综述TCM-CDs在药理活性及其机制的最新研究进展,并对TCM-CDs当前研究的局限性和未来发展方向进行了展望,以期推动TCM-CDs在传统中医药领域的研究应用。Carbon dots(CDs)are novel fluorescent nanoparticles with a particle size of less than 10 nm.Traditional Chinese medicine(TCM)-derived carbon dots(TCM-CDs)are CDs synthesized using TCM as the precursor.Compared to conventional CDs,TCM-CDs utilize natural TCM resources,which are abundant and align with the principles of green chemistry.The rich active components in TCM endow TCM-CDs with unique pharmacological activities and enhanced biocompatibility,which can facilitate drug delivery and targeted therapy,thus potentially enhancing their medicinal value.Moreover,TCM-CDs are cost-effective to prepare,making them suitable for large-scale applications,which further expands their potential value in the biomedical field.Consequently,TCM-CDs have garnered widespread attention and interest in recent years.This review provides a detailed introduction to the sources and preparation methods of TCM-CDs,along with a discussion of the advantages and disadvantages of each preparation method.It systematically summarizes the structural features,properties,and characterization techniques of TCM-CDs,and comprehensively reviews the latest research progress on the pharmacological activities and mechanisms of TCM-CDs.The review also discusses the current limitations of TCM-CDs research and outlines future development directions,with the aim of promoting the research and application of TCMCDs in the field of TCM.

关 键 词：碳点 中药衍生碳点 制备方法 表征方法 药物递送 

分 类 号：R283.3[医药卫生—中药学]