毛蕊异黄酮抗炎作用研究进展  

Research progress on anti-inflammatory effects of calycosin

作　　者：余润宇 赵文昌 杨芷胭 周芸湄 江小英 余俊贤 陈雨欣 冯诗婷 刘凤琳 李子杰 宋丽军 YU Runyu;ZHAO Wenchang;YANG Zhiyan;ZHOU Yunmei;JIANG Xiaoying;YU Junxian;CHENYuxin;FENG Shiting;LIU Fenglin;LI Zijie;SONG Lijun(School of pharmacy,Guangdong Medical University,Dongguan 523808,China;Dongguan Key Laboratory of Screening and Research of Anti-inflammatory Ingredients in Chinese Medicine,Dongguan 523808,China)

机构地区：[1]广东医科大学药学院,广东东莞523808 [2]东莞市中药抗炎活性成分筛选与研究重点实验室,广东东莞523808

出　　处：《中草药》2025年第6期2238-2248,共11页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金面上项目(81973548);广东省高校创新团队项目(2022KCXTD011);湛江市科技计划项目(2021B01139)。

摘　　要：毛蕊异黄酮是主要来源于黄芪的异黄酮类化合物,具有类雌激素作用,并在抗炎、抗肿瘤、抗氧化、抗病毒等方面显示了较好的作用。炎症是免疫系统在对抗各种外部感染时发生的异常过度反应,可导致多个器官的结构功能损伤,近年来,毛蕊异黄酮在抗炎方面的研究报道逐渐增多,显示出其在炎症相关疾病治疗中的潜力。通过总结毛蕊异黄酮在肠道、肾脏、脑和神经、心脏、肺和肝脏等各器官炎性损伤方面的研究进展,为毛蕊异黄酮的临床应用和新药开发提供文献参考依据和科学支持。Calycosin(CA)is an estrogen-like flavonoid compound mainly derived from dried roots of Astragalus membranaceus.It has shown good effects in anti-inflammatory,anti-tumor,antioxidant,antiviral and other aspects.Inflammation is an excessive abnormal immune response,which can lead to structural and functional damage of various organs.In recent years,an increasing number of studies have been reported on the anti-inflammatory effects of CA,which showed its potential in the treatment of inflammation-related diseases.Therefore,this article summarizes the research progress of CA in inflammatory injuries such as intestinal,renal,brain and nervous system,heart,lung and liver,providing literature reference for the clinical application and new drug development of CA.

关 键 词：毛蕊异黄酮 抗炎 抗肿瘤 抗氧化 抗病毒 器官 

分 类 号：R285[医药卫生—中药学]