代谢重编程对巨噬细胞极化的影响研究进展  

Research progress on the effect of metabolic reprogramming on macrophage polarization

作　　者：邵江涛 齐俊愉 韩泽旭 郭学玲 齐奕珂 王英泽[1] SHAO Jiangtao;QI Junyu;HAN Zexu;GUO Xueling;QI Yike;WANG Yingze(College of Food Science and Biology,Hebei University of Science and Technology,Shijiazhuang,Hebei 050018,China)

机构地区：[1]河北科技大学食品与生物学院,河北石家庄050018

出　　处：《河北科技大学学报》2025年第2期196-206,共11页Journal of Hebei University of Science and Technology

基　　金：国家自然科学基金(81760750);河北省自然科学基金(H2020208018,C2020208023);石家庄市重点研发及中小企业创新计划项目(241200253A);河北科技大学博士科研基金项目(QD2023004)。

摘　　要：炎症性疾病的发病机制涉及组织内部复杂的细胞级联反应,巨噬细胞在其中发挥着核心作用。巨噬细胞具有显著的表型可塑性,能够依据炎症阶段的不同而极化为M1型或M2型,以适应其所处的微环境。环境适应性变化促使巨噬细胞进行代谢重编程,为细胞提供必要的能量支持,从而有效参与抗炎反应并调控炎症过程,但代谢重编程在抗炎治疗方面的研究尚不充分。阐述了巨噬细胞在炎症过程中的作用机制及其代谢重编程的最新研究进展,指出了代谢重编程在炎症性疾病治疗方面面临的问题,认为未来巨噬细胞代谢重编程研究应侧重以下几方面:1)探究代谢重编程产物影响巨噬细胞炎症因子产生的机理;2)深入分析代谢重编程调控巨噬细胞的分子机制;3)探索个体差异对巨噬细胞代谢途径调控的影响,以及如何根据这些差异定制个体化的治疗方案。The pathogenesis of inflammatory diseases involves complex cellular cascades within tissues,where macrophages play a pivotal role.These cells exhibit remarkable phenotypic plasticity and can polarize into M1 or M2 types depending on the stage of inflammation to adapt to the microenvironment.Environmental adaptability changes prompt macrophages to undergo metabolic reprogramming,providing necessary energy support for cells to effectively participate in anti-inflammatory responses and regulate inflammatory processes.However,research on metabolic reprogramming in anti-inflammatory therapy remains insufficient.This review systematically described the mechanism of macrophages in inflammation process and the latest research progress on metabolic reprogramming.It pointed out the challenges faced by metabolic reprogramming in treating inflammatory diseases and suggests that future research on macrophage metabolic reprogramming should focus on the following areas:1)exploring the mechanism by which metabolic reprogramming products affect the production of inflammatory cytokines by macrophages;2)conducting an in-depth analysis of the molecular mechanism of metabolic reprogramming in regulating macrophages;3)exploring the effects of individual differences on the regulation of macrophage metabolic pathways and customizing individualized treatment plans based on these differences.

关 键 词：细胞免疫学 炎症反应 巨噬细胞 极化 代谢重编程 

分 类 号：Q28[生物学—细胞生物学]