头皮脂溢性皮炎与头皮微生态相关研究进展  

Research progress on scalp seborrheic dermatitis and scalp microbiome

作　　者：李曼 任伟 张凡 LI Man;REN Wei;ZHANG Fan(Hair Medical Research Center,Department of Dermatology and Venereology,Beijing Jishuitan Hospital,Capital Medical University,Beijing 100035,China)

机构地区：[1]首都医科大学附属北京积水潭医院皮肤科毛发医学研究中心,北京100035 [2]北京大学医学部临床医学院

出　　处：《实用皮肤病学杂志》2025年第1期44-47,共4页Journal of Practical Dermatology

基　　金：北京积水潭医院自然基金培育计划(ZR-202112);北京积水潭医院高层次人才“学科骨干”培养计划(XKGG202120)。

摘　　要：头皮脂溢性皮炎的发病机制尚不清楚,头皮微生态的改变在其中可能发挥重要作用。许多研究表明,与健康人群相比,脂溢性皮炎患者皮肤真菌α-多样性改变,而β-多样性无明显变化,以限制马拉色菌属增加和球形马拉色菌减少为主;细菌α和β-多样性均发生改变,以葡萄球菌属增加和丙酸杆菌属减少为主。头皮微生态代谢功能多样性改变在头皮脂溢性皮炎发病中发挥重要作用,同时还与头皮脂溢性皮炎严重程度、皮肤屏障功能有关。头皮微生态研究可能为头皮脂溢性皮炎治疗提供新思路。The pathogenesis of scalp seborrheic dermatitis remains unclear,and alterations in the scalp microbiome are likely to play a crucial role.Numerous studies have indicated that,compared with healthy individuals,patients with seborrheic dermatitis exhibit changes in theα-diversity of skin fungi,with no significant alterations inβ-diversity.Specifically,there is an increase in the genus Malassezia restricta(M.restricta)and a decrease in Malassezia globosa(M.globosa).Both theα-diversity andβ-diversity of bacteria are altered,mainly characterized by an increase in the genus Staphylococcus and a decrease in the genus Propionibacterium.Alterations in the diversity of scalp microecological metabolic functions play a significant role in the development of scalp seborrheic dermatitis.Moreover,they are associated with the severity of scalp seborrheic dermatitis and the function of the skin barrier.Research on the scalp microbiome may offer new perspectives for the treatment of scalp seborrheic dermatitis.

关 键 词：皮炎 脂溢性 头皮微生态 菌群多样性 综述 

分 类 号：R758.732[医药卫生—皮肤病学与性病学]