糖基化修饰在皮肤病学中的研究进展  

Research progress on glycosylation in skin diseases

作　　者：孙琦 钟欣妮 陈雯婷 李巍[1] SUN Qi;ZHONG Xinni;CHEN Wenting;LI Wei(Department of Dermatology,Children's Hospital of Soochow University,Suzhou 215025,China)

机构地区：[1]苏州大学附属儿童医院皮肤科,苏州215025

出　　处：《实用皮肤病学杂志》2025年第1期55-58,72,共5页Journal of Practical Dermatology

基　　金：苏州市医学应用基础研究项目(SKY2018134)。

摘　　要：糖基化修饰是蛋白质翻译后修饰的重要方式之一,可通过添加糖链的方式对蛋白质进行修饰,以调节其生物活性。近年来,蛋白质糖基化修饰逐渐成为糖组学领域研究的热点,同时异常糖基化修饰在皮肤疾病的发生、发展中具有重要作用。本文就蛋白质糖基化修饰在相关皮肤疾病如恶性黑素瘤、红斑狼疮、自身免疫性大疱病中的作用研究进展进行综述。Glycosylation is one of the crucial post-translational modifications observed in proteins.It modifies proteins by adding sugar chains to regulate their biological activities.In recent years,glycosylation has gradually become a research hotspot in the field of glycomics.Meanwhile,aberrant glycosylation has been implicated in promoting the occurrence and progression of skin diseases.This article reviews the research progress on the role of glycosylation in related skin diseases such as malignant melanoma,lupus erythematosus,and autoimmune bullous diseases.

关 键 词：糖基化 皮肤疾病 皮肤肿瘤 综述 

分 类 号：R751[医药卫生—皮肤病学与性病学] R343[医药卫生—临床医学]