灵芝基因组学及其功能基因研究进展  

Research Progress in Genomics and Functional Genes of Ganoderma lingzhi

作　　者：谢欣 贺黎铭 蔡凌 刘林秋 罗霞[1,2] XIE Xin;HE Li-Ming;CAI Ling;LIU Lin-Qiu;LUO Xia(Laboratory for Systemic Research and Development of Fungal Medicinal Materials,Institute of Fungal Medicinal Materials,Sichuan Academy of Chinese Medicine Sciences,Chengdu 610041,China;Sichuan-Chongqing Joint Key Laboratory of Innovation of New Drugs of Traditional Chinese Medicine,Chengdu 610041,China)

机构地区：[1]四川省中医药科学院菌类药材研究所菌类药材系统研究与开发实验室,成都610041 [2]中药新药创制川渝共建重点实验室,成都610041

出　　处：《农业生物技术学报》2025年第4期898-910,共13页Journal of Agricultural Biotechnology

基　　金：四川省科技厅省级科研院所基本科研业务专项(四川省科技计划资助,2024JDKY0026);菌类药材系统研究与转化创新团队(2022C004);四川道地中药材创新团队项目(SCCXTD-2020-19);重庆市技术创新与应用发展项目(cstc2021jscxgksbX0018)。

摘　　要：灵芝(Ganoderma lingzhi)是一种名贵的食、药用真菌,目前,从其各种组织中分离得到的次级代谢产物种类有200多种,其中灵芝三萜类化合物和灵芝多糖是其主要活性成分;药理学作用主要包括:抗高血压、抗肿瘤、抗衰老、免疫调节作用和对心血管系统疾病的缓解作用等;随着灵芝基因组测序的完成和遗传转化体系的建立,使其逐渐成为研究药用真菌次级代谢产物合成和调控的模式真菌;对灵芝的分子生物学研究涉及种质资源鉴定、遗传多样性、品种育种和功能基因克隆等方面,本文从灵芝的基因组学研究、参与调控灵芝生长发育、代谢产物合成、非生物胁迫以及信号转导的功能基因研究进展等方面进行了总结,为灵芝的进一步开发应用提供参考,也为阐明灵芝疗效的分子机理提供科学依据。Ganoderma lingzhi is a valuable edible and medicinal fungus,at present,there are more than 200kinds of secondary metabolites isolated from various tissues of G.lingzhi,among which G.lingzhi triterpenoids and polysaccharides are its main active ingredients,and their pharmacological effects mainly include anti-hypertensive,anti-tumor,anti-aging,The completion of G.lingzhi genome sequencing and the establishment of genetic transformation system have gradually become a model fungus for the study of the synthesis and regulation of secondary metabolites of medicinal fungi,and its molecular biology research involves the identification of G.lingzhi germplasm resources,genetic diversity,variety breeding,functional gene cloning,etc..In this paper,the research progress of G.lingzhi genomics,functional genes involved in the regulation of G.lingzhi growth and development,metabolite synthesis,abiotic stress and signal transduction were summarized,so as to provide a reference for the further development and application of G.lingzhi and a scientific basis for elucidating the molecular mechanism of G.lingzhi efficacy.

关 键 词：灵芝 基因组学 功能基因 

分 类 号：S567.31[农业科学—中草药栽培]