树突状细胞在过敏性疾病发病中的作用机制和治疗价值  

The role of dendritic cells in the pathogenesis and therapeutic value of allergic diseases

作　　者：毛培 王妍妍 黄功华 MAO Pei;WANG Yanyan;HUANG Gonghua(Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics//Guangdong Medical University,Dongguan 523808,China;School of Medical Technology,Guangdong Medical University,Dongguan 523808,China)

机构地区：[1]广东省医学免疫与分子诊断重点实验室//广东医科大学,广东东莞523808 [2]广东医科大学医学技术学院,广东东莞523808

出　　处：《广东医科大学学报》2025年第2期131-138,共8页Journal of Guangdong Medical University

基　　金：国家自然科学基金(82371758)。

摘　　要：过敏性疾病是机体免疫系统对环境中某些过敏原的不适当或过度的免疫反应而产生的炎症性疾病,其发病机制仍有待阐明。树突状细胞(DC)作为免疫系统的重要上游调节因子,在过敏反应的启动和调控中扮演关键角色,特别是在过敏原的提呈和T细胞免疫反应的诱导过程中。DC在多种过敏性疾病中如过敏性哮喘、特应性皮炎、食物过敏等均发挥重要作用。许多针对DC的治疗策略,尤其是靶向DC的免疫疗法,均源自于对其功能的深入研究。该文概述了DC的生物学特性,探讨了不同DC亚群在过敏性疾病发病机制中的作用,并总结了以DC为中心的治疗进展,为通过靶向DC治疗过敏性疾病提供新策略。Allergic diseases are inflammatory conditions caused by inappropriate or excessive immune responses to certain environmental allergens.The underlying mechanisms remain incompletely understood.Dendritic cell(DC)play a pivotal role as key upstream factors of allergic reactions,particularly in orchestrating allergen presentation and T cell immune response induction.DC are critically implicated in the pathogenesis of diverse allergic diseases,including allergic asthma,atopic dermatitis,and food allergies.Many therapeutic strategies targeting DC in allergic diseases have been developed through functional studies.Here,we review the biological characteristics of DC,discuss the roles of distinct DC subsets in the pathogenesis of allergic diseases,and highlight the advances in DC-centered therapies,providing new strategies for treating allergic diseases by targeting DC.

关 键 词：树突状细胞 过敏性疾病 免疫调节 

分 类 号：R392.8[医药卫生—免疫学]