BiPAP联合氧气驱动雾化吸入布地奈德可改善慢性阻塞性肺疾病急性期合并2型糖尿病患者的临床指标  

BiPAP combined with oxygen-driven budesonide nebulization improves clinical indicators in acute exacerbation of chronic obstructive pulmonary diseases with type 2 diabetes

作　　者：姚观金 林辉斌[1] 黄耀光[1] 马碧蔓[1] YAO Guanjin;LIN Huibin;HUANG Yaoguang;MA Biman(Department II of Respiratory and Critical Care Medicine,Zhanjiang Central People’s Hospital,Zhanjiang 524045,China)

机构地区：[1]湛江中心人民医院呼吸与危重症医学科二科,广东湛江524045

出　　处：《广东医科大学学报》2025年第2期189-193,共5页Journal of Guangdong Medical University

基　　金：湛江市科技计划项目(2021B01334)。

摘　　要：目的观察双水平气道正压通气(BiPAP)联合氧气驱动雾化吸入布地奈德治疗慢性阻塞性肺疾病急性期(AECOPD)合并2型糖尿病(T2DM)患者的疗效。方法110例AECOPD合并T2DM患者随机采用BiPAP(对照组)或BiPAP联合氧气驱动雾化吸入布地奈德(观察组)治疗,疗程均为7 d。比较两组的疗效、不良反应及血气、生命体征、炎症反应、应激反应、糖代谢、肺功能指标。结果与对照组相比,观察组治疗后PaCO_(2)、心率、呼吸、hs-CRP、WBC、MDA、DI均明显降低,而PaO_(2)、SOD、FEV1%和FEV1/FVC明显升高(P<0.01或0.05)。观察组疗效优于对照组(P<0.05)。结论BiPAP联合氧气驱动雾化吸入布地奈德可改善AECOPD合并T2DM患者的血气、生命体征、炎症反应、应激反应和肺功能指标,提高疗效。Objective To observe the efficacy of bi-level positive airway pressure ventilator(BiPAP)and oxygen-driven aerosol inhalation of budesonide in patients with acute exacerbation of chronic obstructive pulmonary diseases(AECOPD)and type 2 diabetes mellitus(T2DM).Methods A total of 110 AECOPD patients with T2DM were randomly treated with BiPAP(control group)or BiPAP plus oxygen-driven budesonide nebulization(observation group)for 7 days.Clinical efficacy,adverse reactions,blood gas,vital signs,inflammatory response,stress response,glucose metabolism,and pulmonary function indexes were compared between two groups.Results Compared with control group,PaCO_(2),heart rate,respiration,hs-CRP,WBC,MDA,DI were significantly decreased,while PaO_(2),SOD,FEV1%and FEV1/FVC increased in observation group(P<0.01 or 0.05).The curative effect was better in observation group than in control group(P<0.05).Conclusion BiPAP combined with oxygen-driven budesonide nebulization can improve the curative effect as well as blood gas,vital signs,inflammatory response,stress response and pulmonary function in patients with AECOPD and T2DM.

关 键 词：慢性阻塞性肺疾病急性期 2型糖尿病 双水平气道正压通气 雾化吸入 布地奈德 

分 类 号：R563.9[医药卫生—呼吸系统]