采用非侵入性光生物调节治疗癫痫  

The Adoption of Non-invasive Photobiomodulation in The Treatment of Epilepsy

作　　者：李奥运 卢占闯 曹丽 陈思 蒋徽 陈长春 陈雷[1,4] LI Ao-Yun;LU Zhan-Chuang;CAO Li;CHEN Si;JIANG Hui;CHEN Chang-Chun;CHEN Lei(School of Materials Science and Engineering,Hefei University of Technology,Hefei 230009,China;Department of Neurology,the Second People’s Hospital of Anhui Province,Hefei 230041,China;School of Medicine,Huainan Union University,Huainan 232038,China;Intelligent Manufacturing Institute of HFUT,Hefei 230051,China)

机构地区：[1]合肥工业大学材料科学与工程学院,合肥230009 [2]安徽省第二人民医院神经内科,合肥230041 [3]淮南联合大学医学院,淮南232038 [4]合肥工业大学智能制造技术研究院,合肥230051

出　　处：《生物化学与生物物理进展》2025年第4期882-898,共17页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(21875058);安徽省自然科学基金(2208085J13);2022年度中山市重大科技专项战略性新兴产业技术攻关专题(2022A1007)资助项目。

摘　　要：癫痫是一种由脑部异常同步放电引起反复发作性神经功能异常的慢性脑部疾病,临床常见以意识不清、四肢抽搐为主要表现特征,各年龄段均可发病,涉及的人口众多。安全、有效以及合理地控制癫痫病情,是脑科学与神经内科学领域挑战之一。目前癫痫的治疗主要为药物治疗,部分难治性患者还需通过手术切除大脑异常放电的区域,但药物治疗后部分患者可出现耐药性或严重的副作用,包括肥胖、肝肾功能损伤和认知功能障碍等,手术治疗费用昂贵且影响神经元之间的相互连接及其功能。在过去侵入性神经调控治疗技术的基础上,发展诸如光生物调节(PBM)这类非侵入性神经调控治疗策略是癫痫治疗先进技术的重要发展动向。PBM通过调节线粒体功能、增强脑膜淋巴管引流和清除毒素功能,抑制神经炎症,刺激突触与神经元生长,改善神经元代谢和网络活动,可以有效减少癫痫发作频率。相比于传统治疗,PBM具有非侵入性、无副作用且能够精准调控神经活动的显著优势,在治疗难治性癫痫方面具有广阔应用前景。本文综述了PBM治疗癫痫的研究进展。Epilepsy is a chronic neurological disease caused by abnormal synchronous discharge of the brain,which is characterized by recurrent and transient neurological abnormalities,mainly manifested as loss of consciousness and limb convulsions,and can occur in people of all ages.At present,anti-epileptic drugs(AEDs)are still the main means of treatment,but their efficacy is limited by the problem of drug resistance,and long-term use can cause serious side effects,such as cognitive dysfunction and vital organ damage.Although surgical resection of epileptic lesions has achieved certain results in some patients,the high cost and potential risk of neurological damage limit its scope of application.Therefore,the development of safe,accurate and personalized non-invasive treatment strategies has become one of the key directions of epilepsy research.In recent years,photobiomodulation(PBM)has gained significant attention as a promising non-invasive therapeutic approach.PBM uses light of specific wavelengths to penetrate tissues and interact with photosensitive molecules within cells,thereby modulating cellular metabolic processes.Research has shown that PBM can enhance mitochondrial function,promote ATP production,improve meningeal lymphatic drainage,reduce neuroinflammation,and stimulate the growth of neurons and synapses.These biological effects suggest that PBM not only holds the potential to reduce the frequency of seizures but also to improve the metabolic state and network function of neurons,providing a novel therapeutic avenue for epilepsy treatment.Compared to traditional treatment methods,PBM is non-invasive and avoids the risks associated with surgical interventions.Its low risk of significant side effects makes it particularly suitable for patients with drug-resistant epilepsy,offering new therapeutic options for those who have not responded to conventional treatments.Furthermore,PBM’s multi-target mechanism enables it to address a variety of complex etiologies of epilepsy,demonstrating its potential in precision

关 键 词：癫痫 病因病理 生物标志物 光生物调节 先进治疗技术 

分 类 号：R454.2[医药卫生—治疗学] R741[医药卫生—临床医学]