E2F家族对肌肉骨骼系统发育和相关疾病的影响  

Effects of E2F Family on Musculoskeletal System Development and Related Diseases

作　　者：王舒莞 汪琢 WANG Shu-Wan;WANG Zhuo(School of Sports Health,Shenyang Sport University,Shenyang 110102,China)

机构地区：[1]沈阳体育学院运动健康学院,沈阳110102

出　　处：《生物化学与生物物理进展》2025年第4期915-929,共15页Progress In Biochemistry and Biophysics

基　　金：2024年辽宁省自然科学基金计划博士科研启动项目(2024-BS-273);辽宁省教育厅2022年基本科研项目(LJKMZ20221610)资助。

摘　　要：E2F家族是介导腺病毒E1a诱导E2基因的转录因子家族,在调控细胞周期进程、调节细胞增殖、诱导细胞凋亡的过程中起着至关重要的作用。鉴于其功能主要与细胞增殖分化有关,早期关于E2F家族的研究多集中于E2F与癌症的关系。随着研究范围的不断扩大,研究者发现,E2F家族在肌肉骨骼系统的发育过程以及相关疾病的作用机制中独立发挥作用。E2F家族可以通过调控干细胞、成骨细胞、破骨细胞、软骨细胞和成肌细胞的细胞周期和增殖过程,并且作为多个通路下游以及微RNA (microRNA)的靶点基因,减缓或加重肌肉骨骼系统疾病进展。目前关于E2F家族在肌肉骨骼系统中的作用还没有系统的总结和梳理,本文主要就E2F家族在肌肉骨骼系统中的生理学功能和E2F家族在肌肉骨骼系统相关疾病中的作用机制进行综述,希望为后续研究和疾病诊疗提供依据。The E2F family consists of transcription factors that mediate the induction of the E2 gene by adenovirus E1a and play a vital role in regulating cell cycle progression,cell proliferation,and cell apoptosis.Given its primary functions in cell proliferation and differentiation,early studies on the E2F family focused on its relationship with cancer.However,as research has expanded,the E2F family has been found to play an independent role in the development of the musculoskeletal system and the mechanisms of related diseases.The E2F family can influence the progression of musculoskeletal diseases by regulating the cell cycle and proliferation of stem cells,osteoblasts,osteoclasts,chondrocytes,and myoblasts,acting as a target gene for various downstream pathways and microRNAs.This review is divided into two parts:the first elaborates on the physiological roles of the E2F family in bone metabolism,skeletal muscle,and cartilage development,while the second summarizes its roles in the pathological processes of osteosarcoma,rheumatoid arthritis,osteoporosis,and muscle-related diseases.During musculoskeletal system development,the E2F family affects bone metabolism by regulating stem cell differentiation,promoting osteoclast differentiation and metabolism,and increasing osteoblast activity or inhibiting osteoblast differentiation.It also regulates mitosis in cartilage,influencing chondrocyte proliferation and differentiation.Additionally,the E2F family is essential for skeletal muscle development,controlling muscle differentiation and myogenesis.In the pathological mechanisms of musculoskeletal diseases,most E2F family members act as downstream targets of various microRNAs,regulating osteosarcoma progression.Some members function independently through their ability to control cell proliferation.The E2F family also contributes to osteoporosis progression by promoting pathological increases in osteoclast activity and affecting osteoblast function.In rheumatoid arthritis and osteoarthritis,E2F family members aggravate inflamm

关 键 词：E2F家族 骨 肌肉 骨肉瘤 骨关节炎 

分 类 号：R336[医药卫生—人体生理学]