生物大分子凝聚体研究相关术语  

Terms Related to The Study of Biomacromolecular Condensates

作　　者：阮科 方晓峰 李丹[3] 李丕龙 吝易 王峥 施蕴渝 张明杰 张宏[6] 刘聪 RUAN Ke;FANG Xiao-Feng;LI Dan;LI Pi-Long;LIN Yi;WANG Zheng;SHI Yun-Yu;ZHANG Ming-Jie;ZHANG Hong;LIU Cong(Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230027,China;School of Life Sciences,Tsinghua University,Beijing 100084,China;Bio-X Institutes,Shanghai Jiao Tong University,Shanghai 200030,China;Institute of Biomedical Innovation,Nanchang University,Nanchang 330031,China;School of Life Sciences,Southern University of Science and Technology,Shenzhen 518055,China;Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;Interdisciplinary Research Center on Biology and Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 201210,China)

机构地区：[1]中国科学技术大学生命科学与医学部,合肥230027 [2]清华大学生命科学学院,北京100084 [3]上海交通大学Bio-X研究院,上海200030 [4]南昌大学生物医学创新研究院,南昌330031 [5]南方科技大学生命科学学院,深圳518055 [6]中国科学院生物物理研究所,北京100101 [7]中国科学院上海有机化学研究所生物与化学交叉研究中心,上海201210

出　　处：《生物化学与生物物理进展》2025年第4期1027-1035,共9页Progress In Biochemistry and Biophysics

摘　　要：蛋白质和RNA等生物大分子通过多价弱相互作用发生相分离,从而形成具有动态特性的液态凝聚体,其进一步发生相转变形成不同物质状态比如胶装或固状的凝聚体。这些凝聚体能够在细胞内对多种生命活动进行精确的时空调控。然而,随着对该领域研究的拓展和深入,相关术语使用的混乱和不规范问题逐渐显现,阻碍了学术交流和科学知识的传播。因此,有必要对生物大分子凝聚体相关术语进行讨论,以明确概念、促进跨学科合作、提高研究效率,从而推动生物大分子凝聚体领域的健康发展。Biomolecular condensates are formed through phase separation of biomacromolecules such as proteins and RNAs.These condensates exhibit liquid-like properties that can futher transition into more stable material states.They form complex internal structures via multivalent weak interactions,enabling precise spatiotemporal regulations.However,the use of inconsistent and non-standardized terminology has become increasingly problematic,hindering academic exchange and the dissemination of scientific knowledge.Therefore,it is necessary to discuss the terminology related to biomolecular condensates in order to clarify concepts,promote interdisciplinary cooperation,enhance research efficiency,and support the healthy development of this field.

关 键 词：生物大分子凝聚体 术语使用建议 

分 类 号：Q6-3[生物学—生物物理学]